N-(1-Methylethyl)-Na(2)-(2-methylpropyl)urea | 106615-48-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: N-(1-Methylethyl)-Na(2)-(2-methylpropyl)urea
• 英文别名: 1-(2-methylpropyl)-3-propan-2-ylurea
• CAS: 106615-48-9
• 化学式: C₈H₁₈N₂O
• mdl: MFCD26794541
• 分子量: 158.24
• InChiKey: UXVCYNDIOFJKFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• [EN] COMPOUNDS AND METHODS FOR MODULATING ADENOSINE A2B RECEPTOR AND ADENOSINE A2A RECEPTOR<br/>[FR] COMPOSÉS ET PROCÉDÉS DE MODULATION DU RÉCEPTEUR A2B DE L'ADÉNOSINE ET DU RÉCEPTEUR A2A DE L'ADÉNOSINE
  申请人：CORVUS PHARMACEUTICALS INC

  公开号：WO2019046784A1

  公开（公告）日：2019-03-07

  Disclosed herein, inter alia, are compositions and methods for modulating Adenosine Receptors. In an aspect is provided a method of inhibiting Adenosine A2B Receptor activity and Adenosine A2A Receptor activity, the method including contacting the Adenosine A2B Receptor and Adenosine A2A Receptor with a compound as described herein, including embodiments.

  在此披露的内容包括调节腺苷受体的组合物和方法。在一个方面，提供了一种抑制腺苷A2B受体活性和腺苷A2A受体活性的方法，该方法包括将腺苷A2B受体和腺苷A2A受体与本文描述的化合物接触，包括各种实施方式。
• Viral Polymerase Inhibitors
  申请人：Beaulieu L. Pierre

  公开号：US20080045516A1

  公开（公告）日：2008-02-21

  Compounds of formula I: wherein X, R 2 , R 3 , R 5 and R 6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.

  式I的化合物： 其中X，R2，R3，R5和R6如本文所定义，可用作乙型肝炎病毒NS5B聚合酶的抑制剂。
• SULFONYL-SUBSTITUTED 6-MEMBERED RING DERIVATIVE
  申请人：Nagase Tsuyoshi

  公开号：US20100249147A1

  公开（公告）日：2010-09-30

  [Problem] To provide a compound that is useful as an agent in the prevention and treatment of circulatory system, nervous system, metabolic, reproductive system, and gastrointestinal diseases. [Means for Resolution] A compound or a pharmaceutically acceptable salt thereof represented by the following Formula (I): [wherein, Z represents formula (II-1), (II-2), or (II-3), wherein m and n are 0, 1, or 2, Y represents CR 3 or N, R 1 represents a C 1-6 alkyl, C 3-8 cycloalkyl, etc., R 2 represents phenyl or a heteroaryl, etc., R 3 and R 4 each independently represent a hydrogen atom, a C 1-6 alkyl, etc., M 1 , M 2 , M 3 , and M 4 each independently represent a hydrogen atom, a C 1-6 alkyl, etc.]

  提供一种化合物，可用作预防和治疗循环系统、神经系统、代谢系统、生殖系统和消化系统疾病的药剂。解决方法为以下式（I）所代表的化合物或其药用盐： [其中，Z代表式（II-1）、（II-2）或（II-3），其中m和n为0、1或2，Y代表CR3或N，R1代表C1-6烷基、C3-8环烷基等，R2代表苯基或杂环烷基等，R3和R4各自独立地代表氢原子、C1-6烷基等，M1、M2、M3和M4各自独立地代表氢原子、C1-6烷基等。]
• LONG-CHAIN FATTY ACYL ELONGASE INHIBITOR COMPRISING ARYLSULFONYL DERIVATIVE AS ACTIVE INGREDIENT
  申请人：Jitsuoka Makoto

  公开号：US20110009622A1

  公开（公告）日：2011-01-13

  [Problem] To provide compounds useful as preventives or remedies for circular system disorders, nervous system disorders, metabolic disorders, reproduction system disorders, digestive system disorders, neoplasm, infectious diseases, etc., or as herbicides. [Means for Solution] A long-chain fatty acyl elongase inhibitor comprising, as the active ingredient thereof, a compound or a pharmaceutically-active salt thereof of a formula (I): [wherein W represents a hydrogen atom, a C 1-6 alkyl, etc.; X represents an aryl, a heteroaryl, etc.; n indicates 0 or 1; Z represents a hydrogen atom, a C 1-6 alkyl, etc.; A 1 , A 2 , A 3 and A 4 each independently represent CH or N].

  提供化合物，可用作循环系统紊乱、神经系统紊乱、代谢紊乱、生殖系统紊乱、消化系统紊乱、肿瘤、传染病等的预防或治疗，或用作除草剂的方法。一种长链脂肪酰基延长酶抑制剂，其作为活性成分包括下述公式（I）的化合物或其药用活性盐：[其中，W代表氢原子、C1-6烷基等；X代表芳基、杂环芳基等；n表示0或1；Z代表氢原子、C1-6烷基等；A1，A2，A3和A4分别独立地代表CH或N]。
• NOVEL PHENYL-ISOXAZOL-3-OL DERIVATIVE
  申请人：Hashimoto Noriaki

  公开号：US20100130559A1

  公开（公告）日：2010-05-27

  The present invention relates to a compound represented by formula (I), which has a GPR120 agonist action and thus is useful for treatment of diabetes mellitus or hyperlipidemia, or a pharmaceutically acceptable salt thereof. In the formula, (AA) represents a phenyl or the like, which may be substituted with a lower alkoxy group or the like; (BB) represents a divalent group or the like, derived by removal of two hydrogen atoms from a benzene which may be substituted with a halogen atom or the like; X represents a spacer having a main chain composed of 1-8 carbon atoms wherein 1-3 carbon atoms in the main chain may be substituted with an oxygen atom or the like; and Y represents a hydrogen atom or the like.

  本发明涉及一种由式(I)所表示的化合物，该化合物具有GPR120激动剂作用，因此可用于治疗糖尿病或高脂血症，或其药学上可接受的盐。在该式中，(AA)代表苯或类似物，可能被低烷氧基或类似物取代；(BB)代表二价基团或类似物，由苯中去除两个氢原子而来，该苯可能被卤原子或类似物取代；X代表具有由1-8个碳原子组成的主链的间隔物，其中主链中的1-3个碳原子可能被氧原子或类似物取代；而Y代表氢原子或类似物。