7-Fluoro-2,1,3-benzothiadiazole-4-sulfonic acid | 743418-72-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻二唑类
• 英文名称: 7-Fluoro-2,1,3-benzothiadiazole-4-sulfonic acid
• CAS: 743418-72-6
• 化学式: C₆H₃FN₂O₃S₂
• 分子量: 234.2
• InChiKey: RYDVSPKPBTYQKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  117
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Method of Detection, Separation and Identification for Expressed Trace Protein/Peptide
  申请人：Imai Kazuhiro

  公开号：US20080280316A1

  公开（公告）日：2008-11-13

  A method of detection separation and identification for expressed trace protein/peptide; and a system therefor. There is provided a method of detecting, separating and identifying a minute amount of expressed protein and/or peptide, characterized in that a fluorescent derivative of protein and/or peptide contained in a test subject sample having been labeled with a fluorescence reagent is applied to HPLC; a fluorescent fraction is collected and subjected to enzymatic hydrolysis; mass-spectrometry of the resultant fluorescence-labeled fragments and non-fluorescence-labeled fragments is carried out; and the thus obtained ion molecular weight information on each of the fragments is collated with an available protein and/or peptide fragment database to thereby accomplish a structural analysis. Further, there is provided an identification system therefor.

  一种用于检测、分离和鉴定表达微量蛋白质/肽的方法；以及用于该方法的系统。提供了一种检测、分离和鉴定微量表达蛋白质和/或肽的方法，其特征在于将标记有荧光试剂的蛋白质和/或肽的荧光衍生物应用于高效液相色谱（HPLC）；收集荧光分离物并进行酶解水解；质谱分析所得的荧光标记片段和非荧光标记片段；然后将每个片段的离子分子量信息与可用的蛋白质和/或肽片段数据库进行匹配，以完成结构分析。此外，还提供了一个鉴定系统。
• METHOD OF DETECTION, SEPARATION AND IDENTIFICATION FOR EXPRESSED TRACE PROTEIN/PEPTIDE
  申请人：Imai, Kazuhiro

  公开号：EP1705482A2

  公开（公告）日：2006-09-27

  A method of detection, separation and identification for expressed trace protein/peptide; and a system therefor. There is provided a method of detecting, separating and identifying a minute amount of expressed protein and/or peptide, characterized in that a fluorescent derivative of protein and/or peptide contained in a test subject sample having been labeled with a fluorescence reagent is applied to HPLC; a fluorescent fraction is collected and subjected to enzymatic hydrolysis; mass-spectrometry of the resultant fluorescence-labeled fragments and non-fluorescence-labeled fragments is carried out; and the thus obtained ion molecular weight information on each of the fragments is collated with an available protein and/or peptide fragment database to thereby accomplish a structural analysis. Further, there is provided an identification system therefor.

  一种检测、分离和鉴定表达的微量蛋白质/肽的方法及其系统。本发明提供了一种检测、分离和鉴定微量表达蛋白和/或肽的方法，其特征在于：将检测对象样品中含有的用荧光试剂标记的蛋白和/或肽的荧光衍生物应用于高效液相色谱法；收集荧光馏分并进行酶水解；对由此产生的荧光标记片段和非荧光标记片段进行质谱分析；将由此获得的每个片段的离子分子量信息与现有的蛋白质和/或肽片段数据库进行核对，从而完成结构分析。此外，还为此提供了一种识别系统。
• US8796037B2
  申请人：——

  公开号：US8796037B2

  公开（公告）日：2014-08-05