[(8R,9S,10S)-9-hydroxy-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-8-yl] benzoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 英文名称: [(8R,9S,10S)-9-hydroxy-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-8-yl] benzoate
• 化学式: C₃₀H₃₂O₉
• 分子量: 536.6
• InChiKey: UFCGDBKFOKKVAC-IZDNNGBCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Extracts with liver-X-receptor modulators, compounds and their use in weight control and treatment of disorders of lipid metabolism
  申请人：InterMed Discovery GmbH

  公开号：EP2025335A1

  公开（公告）日：2009-02-18

  The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, of an extract and/or one or more natural compounds from plants or parts of plants, respectively, from a genus selected from the group consisting of Schisandra, Illicium, Kadsura, Steganotaenia and Magnolia, alone or as supplement, as active ingredient in the regulation of body weight and/or fat loss and/or for the management of obesity, either in humans or in animals, to the use of said extract and/or natural compound(s) or mixtures in the manufacture of a pharmaceutical or nutraceutical formulation for the regulation of body weight and/or fat loss and/or for the management of obesity either in humans or in animals. The above extract and/or compound(s) can further be used to reduce one or more adverse metabolic parameters in a subject, such as the blood cholesterol level, especially the "bad" low density lipid (LDL) cholesterol. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament for the treatment of obesity and/or elevated blood cholesterol, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in the regulation of body weight and/or fat loss and/or for the management of obesity.

  本发明涉及使用来自植物属Schisandra、Illicium、Kadsura、Steganotaenia和Magnolia的提取物和/或一种或多种天然化合物的用途或方法（特别是针对需要此类治疗的动物，尤其是人类），作为单独的活性成分或补充剂，在调节体重和/或减脂和/或管理肥胖方面的应用，无论是在人类还是动物中，以及在制造用于调节体重和/或减脂和/或管理肥胖的药物或营养保健品制剂中使用所述提取物和/或天然化合物或混合物。上述提取物和/或化合物还可以用于减少受试者的一个或多个不良代谢参数，例如血胆固醇水平，特别是“坏”的低密度脂蛋白（LDL）胆固醇。本发明还涉及所述提取物和/或化合物的用于肥胖和/或高血胆固醇治疗或制备药物的用途，以及它们的制备。还涉及包括所述提取物和/或天然化合物的药物或营养保健品制剂，其在调节体重和/或减脂和/或管理肥胖方面有用。
• Glycan therapeutics and related methods thereof
  申请人：KALEIDO BIOSCIENCES, INC.

  公开号：US10314853B2

  公开（公告）日：2019-06-11

  Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said gycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.

  本发明提供了可选择包含微量营养素、多酚、益生元、益生菌或其他制剂的聚糖疗法制剂、药物组合物及其医用食品，以及制造方法。还提供了使用所述糖治疗剂的方法，例如用于调节人类胃肠道微生物群和治疗菌群失调。
• Compositions including sesamin, methods of making and using the same in skin anti-aging and skin lightening applications
  申请人：Access Business Group International LLC

  公开号：US10383806B2

  公开（公告）日：2019-08-20

  Topical compositions, packaging systems and methods for improving the appearance of skin or at least one sign of aging in skin are described.

  本文描述了用于改善皮肤外观或至少一种皮肤老化迹象的外用组合物、包装系统和方法。
• Glycan therapeutics and method of treating conditions associated with TMAO
  申请人：Kaleido Biosciences, Inc.

  公开号：US11229660B2

  公开（公告）日：2022-01-25

  Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said gycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.

  本发明提供了可选择包含微量营养素、多酚、益生元、益生菌或其他制剂的聚糖疗法制剂、药物组合物及其医用食品，以及制造方法。还提供了使用所述糖治疗剂的方法，例如用于调节人类胃肠道微生物群和治疗菌群失调。
• Compositions, methods, and medical compositions for treatment of and maintaining the health of the liver
  申请人：Unigen, Inc.

  公开号：US11331359B2

  公开（公告）日：2022-05-17

  Compositions and methods for treatment of and maintaining the health of the liver are disclosed that include a mixture of plant extracts, wherein the plant extracts comprise at least one Artemisia extract, at least one Aloe gel powder, and at least one Schizandra extract. Compositions and methods for treatment of and maintaining the health of the liver are disclosed that include a mixture of plant extracts, wherein the plant extracts comprise at least one Artemisia extract enriched for at least one polymer or biopolymer, at least one Aloe gel powder enriched for at least one chromone, and at least one Schizandra extract enriched for at least one lignan and organic acid.

  公开了治疗和维持肝脏健康的组合物和方法，其中包括植物提取物的混合物，其中植物提取物包括至少一种青蒿提取物、至少一种芦荟凝胶粉和至少一种五味子提取物。公开了治疗和维护肝脏健康的组合物和方法，其中包括植物提取物的混合物，其中植物提取物包括至少一种富含至少一种聚合物或生物聚合物的青蒿提取物、至少一种富含至少一种色酮的芦荟凝胶粉，以及至少一种富含至少一种木质素和有机酸的五味子提取物。