3',5'-Cyclic amp hydrate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 3',5'-Cyclic amp hydrate
• 英文别名: (4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol;hydrate
• 化学式: C10H14N5O7P
• 分子量: 347.22
• InChiKey: GXYGERHACAPJMO-MCDZGGTQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.64
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  156
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• PORTABLE APPARATUS AND METHOD FOR DETECTION OF METHYLXANTHINE CHEMICAL SPECIES
  申请人：——

  公开号：US20010009758A1

  公开（公告）日：2001-07-26

  A portable apparatus for detecting the presence of methylxanthine chemical species such as caffeine or theophylline in a solution such as a beverage comprises a first portion comprising an effective concentration of at least one phosphodiesterase enzyme, a second portion comprising an effective concentration of cyclic AMP, and means for indicating the inhibition of the degradation of cyclic AMP by phosphodiesterase due to the presence of at least one methylxanthine compound. A method for determining the presence of methylxanthine chemical species in a solution such as a beverage comprises contacting at least one test portion of the solution with effective concentrations of at least one phosphodiesterase enzyme and cyclic AMP, and thereafter contacting the test portion with means for indicating the inhibition of the degradation of cyclic AMP by phosphodiesterase due to the presence of at least one methylxanthine compound. The apparatus and method are advantageous in that they provide a simple and effective means of determining whether methylxanthine chemical species such as caffeine or theophylline are present in solutions such as coffee, tea and other beverages.

  一种用于检测饮料等溶液中是否存在咖啡因或茶碱等甲基黄嘌呤化学物质的便携式仪器，包括第一部分，其中含有有效浓度的至少一种磷酸二酯酶；第二部分，其中含有有效浓度的环磷酸腺苷；以及用于指示由于存在至少一种甲基黄嘌呤化合物而抑制磷酸二酯酶降解环磷酸腺苷的装置。一种确定饮料等溶液中是否存在甲基黄嘌呤化学物质的方法，包括将溶液中的至少一个测试部分与有效浓度的至少一种磷酸二酯酶和环 AMP 接触，然后将测试部分与用于显示至少一种甲基黄嘌呤化合物的存在对磷酸二酯酶降解环 AMP 的抑制作用的装置接触。 该装置和方法的优点在于，它们提供了一种简单有效的方法来确定咖啡、茶和其他饮料等溶液中是否存在咖啡碱或茶碱等甲基黄嘌呤化学物质。