[2-(5-bromo-2-ethoxyanilino)cyclohexyl]methyl 4-(1H-indol-4-yl)piperazine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: [2-(5-bromo-2-ethoxyanilino)cyclohexyl]methyl 4-(1H-indol-4-yl)piperazine-1-carboxylate
• 化学式: C₂₈H₃₅BrN₄O₃
• 分子量: 555.5
• InChiKey: FTPJOSBQTMFTLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  69.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Sigma ligands for use in the prevention and/or treatment of postoperative pain
  申请人：Laboratorios del. Dr. Esteve, S.A.

  公开号：EP2353598A1

  公开（公告）日：2011-08-10

  The invention refers to the use of a sigma ligand, particularly a sigma ligand of formulae (I), (II) or (III) to prevent and/or treat acute and chronic pain developed as a consequence of surgery, especially superficial and/or deep pain secondary to surgical tissue injury, and peripheral neuropathic pain, neuralgia, allodynia, causalgia, hyperalgesia, hyperesthesia, hyperpathia, neuritis or neuropathy secondary to surgical procedure.

  本发明涉及使用sigma配体，特别是公式（I），（II）或（III）的sigma配体，以预防和/或治疗由手术引起的急性和慢性疼痛，特别是手术组织损伤引起的表浅和/或深层疼痛，以及周围神经病理性疼痛，神经痛，触痛，烧伤性痛，痛觉过敏，疼痛过敏，神经炎或手术过程引起的神经病变。
• Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1787679A1

  公开（公告）日：2007-05-23

  The present invention refers to the use of compounds active on the sigma receptor for the production of a medicament for the treatment of diabetes-associated pain.

  本发明是指利用对 sigma 受体具有活性的化合物来生产治疗糖尿病相关疼痛的药物。
• Use of compounds binding to the sigma receptor ligands for the treatment of neuropathic pain developing as a consequence of chemotherapy
  申请人：Laboratorios Del. Dr. Esteve, S.A.

  公开号：EP2090311A1

  公开（公告）日：2009-08-19

  The present invention refers to the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy.

  本发明是指使用与西格玛受体结合的化合物来治疗或预防化疗引起的神经性疼痛。
• Use of sigma ligands in bone cancer pain
  申请人：Laboratorios del. Dr. Esteve, S.A.

  公开号：EP2460519A1

  公开（公告）日：2012-06-06

  The invention refers to the use of a sigma ligand, particularly a sigma ligand of formula (I) to prevent and/or treat pain associated to bone cancer.

  本发明是指使用σ配体，特别是式(I)的σ配体来预防和/或治疗与骨癌相关的疼痛。
• USE OF SIGMA LIGANDS IN BONE CANCER PAIN
  申请人：Laboratorios del Dr. Esteve, S.A.

  公开号：EP2646025B1

  公开（公告）日：2017-03-15