7-methoxy-N-[5-[4-(2-methoxyphenyl)piperazin-1-yl]pentyl]quinolin-2-amine | 1013060-17-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 7-methoxy-N-[5-[4-(2-methoxyphenyl)piperazin-1-yl]pentyl]quinolin-2-amine
• CAS: 1013060-17-7
• 化学式: C₂₆H₃₄N₄O₂
• 分子量: 434.582
• InChiKey: UAEMHPQLJHXPFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  49.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氯-7-甲氧基喹啉 、 5-(4-(2-methoxyphenyl)piperazin-1-yl)pentan-1-amine 反应 5.0h， 以30%的产率得到7-methoxy-N-[5-[4-(2-methoxyphenyl)piperazin-1-yl]pentyl]quinolin-2-amine
  参考文献：
  名称：

  N-[ω-[4-(2-Methoxyphenyl)-1-piperazinyl]alkyl]-2-quinolinamines as High-Affinity Fluorescent 5-HT1A Receptor Ligands

  摘要：

  We here report on the design, synthesis; binding affinities, and fluorescent properties of a series of serotonin 5-HT1A receptor ligands, with N-[omega-[4-(2-methoxyphenyl)-1-piperazinyl]alkyl]-2-quinolinamine structure. Several of the new ligands displayed nanomolar affinity at 5-HT1A receptor and good fluorescent properties. In particular, derivative 24 showed a favorable combination of 5-HT1A receptor affinity (K-i = 0.4 nM), Stokes shift (excitation wavelength = 381 nm, emission wavelength = 455 nm), and quantum yield in ethanol (Phi = 0.45).

  DOI：

  10.1021/jm7013919

文献信息

• N-[ω-[4-(2-Methoxyphenyl)-1-piperazinyl]alkyl]-2-quinolinamines as High-Affinity Fluorescent 5-HT1A Receptor Ligands
  作者：Enza Lacivita、Marcello Leopoldo

  DOI：10.1021/jm7013919

  日期：2008.3.13

  We here report on the design, synthesis; binding affinities, and fluorescent properties of a series of serotonin 5-HT1A receptor ligands, with N-[omega-[4-(2-methoxyphenyl)-1-piperazinyl]alkyl]-2-quinolinamine structure. Several of the new ligands displayed nanomolar affinity at 5-HT1A receptor and good fluorescent properties. In particular, derivative 24 showed a favorable combination of 5-HT1A receptor affinity (K-i = 0.4 nM), Stokes shift (excitation wavelength = 381 nm, emission wavelength = 455 nm), and quantum yield in ethanol (Phi = 0.45).