N,N-dimethyl-4-(2-carboxypyrimidin-4-yl)-1-piperazinesulfonamide | 1035587-63-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N,N-dimethyl-4-(2-carboxypyrimidin-4-yl)-1-piperazinesulfonamide
• 英文别名: 4-(4-dimethylsulfamoylpiperazin-1-yl)pyrimidine-2-carboxylic acid；4-[4-(Dimethylsulfamoyl)piperazin-1-yl]pyrimidine-2-carboxylic acid
• CAS: 1035587-63-3
• 化学式: C₁₁H₁₇N₅O₄S
• 分子量: 315.353
• InChiKey: JCIDBJSARCRNQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  N,N-dimethyl-4-[2-(ethoxycarbonyl)pyrimidin-4-yl]-1-piperazinesulfonamide 在 水 作用下， 反应 15.0h， 以77%的产率得到N,N-dimethyl-4-(2-carboxypyrimidin-4-yl)-1-piperazinesulfonamide
  参考文献：
  名称：

  Synthesis and Biological Evaluations of New Pyrrolo[2,3-b]pyrimidine as SDI Analogs

  摘要：

  The synthesis of new pyrrolo[2,3-d]pyrimidines variously substituted on the N-1 and C-2 atoms are described. Access to these compounds, which have modest activity compared with the first inhibitor SDI, involves, as the key step, the formation of a pyrrolopyrimidine skeleton from the 5-amino-2-(methoxymethyl)pyrimidine.

  DOI：

  10.3987/com-07-11302

文献信息

• Synthesis and Biological Evaluations of New Pyrrolo[2,3-b]pyrimidine as SDI Analogs
  作者：Jérôme Guillard、Marie-Claude Viaud-Massuard

  DOI：10.3987/com-07-11302

  日期：——

  The synthesis of new pyrrolo[2,3-d]pyrimidines variously substituted on the N-1 and C-2 atoms are described. Access to these compounds, which have modest activity compared with the first inhibitor SDI, involves, as the key step, the formation of a pyrrolopyrimidine skeleton from the 5-amino-2-(methoxymethyl)pyrimidine.