4-(4-methanesulfonylpiperazin-1-yl)-7-trifluoromethylquinoline | 1624602-40-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-methanesulfonylpiperazin-1-yl)-7-trifluoromethylquinoline
• 英文别名: VR-38；4-(4-Methylsulfonylpiperazin-1-yl)-7-(trifluoromethyl)quinoline；4-(4-methylsulfonylpiperazin-1-yl)-7-(trifluoromethyl)quinoline
• CAS: 1624602-40-9
• 化学式: C₁₅H₁₆F₃N₃O₂S
• 分子量: 359.372
• InChiKey: NSKSCKAEHAVZLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  61.9
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] QUINOLINE SULFONYL DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE LA SULFONYLE QUINOLÉINE ET APPLICATIONS ASSOCIÉES
  申请人：ADVANCED MEDICAL RES INST OF CANADA

  公开号：WO2014134705A1

  公开（公告）日：2014-09-12

  The present disclosure relates to quinoline sulfonyl compounds, compositions comprising these compounds and their use, in particular for the treatment of cancer. In particular, the present disclosure includes compounds of Formula (I), and compositions and uses thereof.

  本公开涉及喹啉磺酰化合物，包含这些化合物的组合物及其用途，特别是用于癌症治疗。具体而言，本公开包括式（I）的化合物，以及其组合物和用途。
• QUINOLINE SULFONYL DERIVATIVES AND USES THEREOF
  申请人：Advanced Medical Research Institute Of Canada

  公开号：EP2964625A1

  公开（公告）日：2016-01-13
• Quinoline Sulfonyl Derivatives And Uses Thereof
  申请人：ADVANCED MEDICAL RESEARCH INSTITUTE OF CANADA

  公开号：US20150376132A1

  公开（公告）日：2015-12-31

  The present disclosure relates to quinoline sulfonyl compounds, compositions comprising these compounds and their use, in particular for the treatment of cancer. In particular, the present disclosure includes compounds of Formula (I), and compositions and uses thereof:
• US9975852B2
  申请人：——

  公开号：US9975852B2

  公开（公告）日：2018-05-22