2-(4-benzylpiperazin-1-yl)-N-[(E)-(2-methylphenyl)methylideneamino]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-benzylpiperazin-1-yl)-N-[(E)-(2-methylphenyl)methylideneamino]acetamide
• 化学式: C₂₁H₂₆N₄O
• 分子量: 350.5
• InChiKey: JYEYXCGQXCYDAQ-PXLXIMEGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Compositions and Methods Including Cell Death Inducers and Procaspase Activation
  申请人：HERGENROTHER Paul J.

  公开号：US20110257398A1

  公开（公告）日：2011-10-20

  Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.
• COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20170105989A1

  公开（公告）日：2017-04-20

  Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.
• US9522901B2
  申请人：——

  公开号：US9522901B2

  公开（公告）日：2016-12-20