N-[2-[[4-Methyl-3-(methylamino)-1-piperidinyl]sulfonyl]ethyl]propanamide | 344419-26-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-[2-[[4-Methyl-3-(methylamino)-1-piperidinyl]sulfonyl]ethyl]propanamide
• 英文别名: N-[2-[4-methyl-3-(methylamino)piperidin-1-yl]sulfonylethyl]propanamide
• CAS: 344419-26-7
• 化学式: C₁₂H₂₅N₃O₃S
• 分子量: 291.41
• InChiKey: LHRVZJSKNRJHLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  86.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Method of treatment of atherosclerosis
  申请人：Changelian S. Paul

  公开号：US20050113395A1

  公开（公告）日：2005-05-26

  A method of treating or preventing atherosclerosis comprising administering a compound of the formula wherein R 1 , R 2 and R 3 are as defined above.

  一种治疗或预防动脉粥样硬化的方法，包括给予一个符合以下公式的化合物，其中R1、R2和R3如上定义。
• Pyrrolo[2,3-d]pyrimidine compounds
  申请人：——

  公开号：US20010053782A1

  公开（公告）日：2001-12-20

  A compound of the formula 1 wherein R 1 , R 2 and R 3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.

  化合物的公式为1，其中R1，R2和R3如上所定义，它们是蛋白激酶抑制剂，例如Janus Kinase 3，并且作为免疫抑制剂治疗器官移植，异种移植，狼疮，多发性硬化症，类风湿性关节炎，银屑病，1型糖尿病和糖尿病并发症，癌症，哮喘，特应性皮炎，自身免疫性甲状腺疾病，溃疡性结肠炎，克罗恩病，阿尔茨海默病，白血病和其他自身免疫性疾病中有用。
• Method of treatment of transplant rejection
  申请人：Pfizer Inc

  公开号：US20040116449A1

  公开（公告）日：2004-06-17

  A method of treating or preventing chronic organ transplant rejection comprising administering a compound of the formula 1 wherein R 1 , R 2 and R 3 are as defined above.

  一种治疗或预防器官移植慢性排异反应的方法，包括给予以下式子中R1、R2和R3如上定义的化合物1。
• Pyrrolo[2,3-D]pyrimidine compounds
  申请人：Blumenkopf A. Todd

  公开号：US20050288313A1

  公开（公告）日：2005-12-29

  A compound of the formula wherein R 1 , R 2 and R 3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.

  该化合物的化学式为其中R1、R2和R3如上所定义，它们是蛋白激酶（如Janus Kinase 3）的抑制剂，因此可用作免疫抑制剂治疗器官移植、异种移植、狼疮、多发性硬化症、类风湿性关节炎、银屑病、1型糖尿病及糖尿病并发症、癌症、哮喘、特应性皮炎、自身免疫性甲状腺疾病、溃疡性结肠炎、克罗恩病、阿尔茨海默病、白血病和其他自身免疫性疾病的治疗。
• PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS
  申请人：Blumenkopf A. Todd

  公开号：US20070292430A1

  公开（公告）日：2007-12-20

  A compound of the formula wherein R 1 , R 2 and R 3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.

  该化合物的化学式为其中R1、R2和R3如上所定义，它们是蛋白激酶抑制剂，如Janus Kinase 3，并且作为免疫抑制剂用于器官移植、异种移植、狼疮、多发性硬化症、类风湿性关节炎、牛皮癣、I型糖尿病及糖尿病并发症、癌症、哮喘、特应性皮炎、自身免疫性甲状腺疾病、溃疡性结肠炎、克罗恩病、阿尔茨海默病、白血病和其他自身免疫性疾病的有用治疗药物。