4-(2-Chlorophenyl)sulfonyl-6-methyl-8-piperazin-1-yl-2,3-dihydro-1,4-benzoxazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(2-Chlorophenyl)sulfonyl-6-methyl-8-piperazin-1-yl-2,3-dihydro-1,4-benzoxazine
• 化学式: C₁₉H₂₂ClN₃O₃S
• 分子量: 407.9
• InChiKey: AQNHXFSXXLNAMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  70.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Benzoxazine derivatives and uses thereof
  申请人：Berger Jacob

  公开号：US20050130962A1

  公开（公告）日：2005-06-16

  The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , Y, Z 1 , m, n, and p are as defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.

  本发明提供了一种公式化合物：其中R1，R2，R3，R4，R5，R6，R8，R9，Y，Z1，m，n和p如本文所定义的药物可接受盐或其前药。本发明还提供了包含该化合物的组合物，使用该化合物的方法以及制备公式I化合物的方法。
• BENZOXAZINE DERIVATIVES AND USES THEREOF
  申请人：Berger Jacob

  公开号：US20130123251A1

  公开（公告）日：2013-05-16

  The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , Y, Z 1 , m, n, and p are as defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.

  本发明提供了一种公式化合物：其为药物可接受的盐或其前药，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、Y、Z1、m、n和p的定义如本文所述。本发明还提供了包含该化合物的组合物、使用该化合物的方法和制备公式I化合物的方法。
• BENZOXAZINE DERIVATIVES AS 5-HT6 MODULATORS AND USES THEREOF
  申请人：F. Hoffmann-La Roche AG

  公开号：EP1506179A1

  公开（公告）日：2005-02-16
• COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY
  申请人：Codony-Soler Xavier

  公开号：US20100120747A1

  公开（公告）日：2010-05-13

  The present invention relates to an active substance combination comprising at least one compound with 5-HT6 receptor affinity, and at least one cholinesterase inhibitor, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.
• US8377931B2
  申请人：——

  公开号：US8377931B2

  公开（公告）日：2013-02-19