Ac-pA | 14114-64-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: Ac-pA
• 英文别名: N⁶-acetyl-[5']adenylic acid；N-acetyl-adenosine-phosphoric acid；N-Acetyladenosine 5'-(dihydrogen phosphate)；[(2R,3S,4R,5R)-5-(6-acetamidopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
• CAS: 14114-64-8
• 化学式: C₁₂H₁₆N₅O₈P
• 分子量: 389.261
• InChiKey: HEIJLJLFABINGL-WOUKDFQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  189
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• N-acetylamino acids, related N-acetyl compounds and their topical use
  申请人：——

  公开号：US20030198656A1

  公开（公告）日：2003-10-23

  Compositions comprising N-acetylamino acids and/or related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors. The N-acetylamino acid and/or related N-acetyl compound composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

  由 N-乙酰基氨基酸和/或相关 N-乙酰基化合物组成的组合物可用于缓解或改善各种美容状况和皮肤病，包括与内在老化和/或外在老化相关的皮肤、指甲和头发的变化或损伤，以及由外在因素引起的变化或损伤。N-acetylamino acid 和/或相关 N-acetyl 化合物组合物可进一步包含化妆品、药物或其他外用制剂，以增强或产生协同效应。
• N-acetyl cysteine and its topical use
  申请人：——

  公开号：US20030229141A1

  公开（公告）日：2003-12-11

  Methods to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors using compositions comprising N-acetyl-cysteine (isomeric or non-isomeric forms) and/or free acid, salt, lactone, amide or ester forms of N-acetyl-cysteine are described. The methods provided may also comprise application of a composition further containing various cosmetic, pharmaceutical or other topical agents to enhance or create synergetic effects.

  本文描述了使用包含 N-乙酰-半胱氨酸（异构体或非异构体形式）和/或 N-乙酰-半胱氨酸的游离酸、盐、内酯、酰胺或酯形式的组合物来缓解或改善各种美容状况和皮肤病的方法，包括与内在老化和/或外在老化相关的皮肤、指甲和头发的变化或损伤，以及外在因素引起的变化或损伤。所提供的方法还可包括使用进一步含有各种化妆品、药物或其他外用制剂的组合物，以增强或产生协同效应。
• US6808716B2
  申请人：——

  公开号：US6808716B2

  公开（公告）日：2004-10-26
• [EN] N-ACETYLAMINO ACIDS, RELATED N-ACETYL COMPOUNDS AND THEIR TOPICAL USE<br/>[FR] ACIDES N-ACETYLAMINES, COMPOSES DE N-ACETYLES ET LEUR UTILISATION TOPIQUE
  申请人：YU RUEY J

  公开号：WO2004089329A2

  公开（公告）日：2004-10-21

  Compositions comprising N-acetylamino acids and/or related N-acetyl compounds are useful to alleviate or improve various cosmetic conditions and dermatological disorders, including changes or damage to skin, nail and hair associated with intrinsic aging and/or extrinsic aging, as well as changes or damage caused by extrinsic factors. The N-acetylamino acid and/or related N-acetyl compound composition may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.