2,6-Dimethyl-1-prop-2-enylpiperazine | 1017199-28-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2,6-Dimethyl-1-prop-2-enylpiperazine
• CAS: 1017199-28-8
• 化学式: C₉H₁₈N₂
• 分子量: 154.255
• InChiKey: RXOYVDIHVKILTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-Dimethyl-1-prop-2-enylpiperazine 、 胆固醇甲酰氯 以 二氯甲烷 为溶剂， 生成 cholest-5-en-3-yl 4-allyl-3,5-dimethyl-1-piperazinecarboxylate
  参考文献：
  名称：

  Efficient nucleic acid transduction with lipoplexes containing novel piperazine- and polyamine-conjugated cholesterol derivatives

  摘要：

  To advance the use of cationic lipids for non-viral nucleic acid vector formulation, a panel of novel nitrogen heterocycle cholesteryl derivatives containing a biodegradable carbamate linker was synthesised. Optimally acting piperazine and cyclen compounds had nucleic acid-binding and lipoplex nanoparticle formation properties that were suitable for their use as non-viral vectors. It was found that the lipoplexes formed were capable of efficient non-toxic nucleic acid delivery to cells in culture. The chemical structure of individual cationic lipids, which is likely to influence lipoplex formation, affected efficiency of DNA or RNA transfection. The results indicated that the cyclen containing compound possessing two cholesteryl moieties resulted in efficient siRNA-mediated target gene silencing but was a poor reagent for DNA transfection. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.009

文献信息

• Anti-cancer compounds
  申请人：Stewart M. John

  公开号：US20060183772A1

  公开（公告）日：2006-08-17

  The invention provides bradykinin antagonists and pharmaceutically acceptable salts thereof having anti-cancer activity. These anti-cancer compounds are particularly useful for inhibiting the growth of lung and prostate cancers.

  本发明提供了具有抗癌活性的缓激肽拮抗剂及其药学上可接受的盐类。这些抗癌化合物特别适用于抑制肺癌和前列腺癌的生长。
• Efficient nucleic acid transduction with lipoplexes containing novel piperazine- and polyamine-conjugated cholesterol derivatives
  作者：Rafique Ul Islam、Justin Hean、Willem A.L. van Otterlo、Charles B. de Koning、Patrick Arbuthnot

  DOI：10.1016/j.bmcl.2008.11.009

  日期：2009.1

  To advance the use of cationic lipids for non-viral nucleic acid vector formulation, a panel of novel nitrogen heterocycle cholesteryl derivatives containing a biodegradable carbamate linker was synthesised. Optimally acting piperazine and cyclen compounds had nucleic acid-binding and lipoplex nanoparticle formation properties that were suitable for their use as non-viral vectors. It was found that the lipoplexes formed were capable of efficient non-toxic nucleic acid delivery to cells in culture. The chemical structure of individual cationic lipids, which is likely to influence lipoplex formation, affected efficiency of DNA or RNA transfection. The results indicated that the cyclen containing compound possessing two cholesteryl moieties resulted in efficient siRNA-mediated target gene silencing but was a poor reagent for DNA transfection. (C) 2008 Elsevier Ltd. All rights reserved.
• ANTI-CANCER COMPOUNDS
  申请人：Stewart John M.

  公开号：US20090088454A1

  公开（公告）日：2009-04-02

  The invention provides bradykinin antagonists and pharmaceutically acceptable salts thereof having anti-cancer activity. These anti-cancer compounds are particularly useful for inhibiting the growth of lung and prostate cancers.
• US7427496B2
  申请人：——

  公开号：US7427496B2

  公开（公告）日：2008-09-23
• US7858349B2
  申请人：——

  公开号：US7858349B2

  公开（公告）日：2010-12-28