(2R,4R)-4-(tert-butyldiphenylsilyloxy)-2,6-dimethylheptan-1-ol | 1040132-19-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (2R,4R)-4-(tert-butyldiphenylsilyloxy)-2,6-dimethylheptan-1-ol
• 英文别名: (2R,4R)-4-[tert-butyl(diphenyl)silyl]oxy-2,6-dimethylheptan-1-ol
• CAS: 1040132-19-1
• 化学式: C₂₅H₃₈O₂Si
• 分子量: 398.661
• InChiKey: RGENMYHESNXRCO-FGZHOGPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.0
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2R,4R)-4-(tert-butyldiphenylsilyloxy)-2,6-dimethylheptan-1-ol 在 咪唑 、 碘 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以92%的产率得到tert-butyl ((2R,4R)-1-iodo-2,6-dimethylheptan-4-yloxy)diphenylsilane
  参考文献：
  名称：

  Asymmetric Hydrogenation Approaches to Valuable, Acyclic 1,3-Hydroxymethyl Chirons

  摘要：

  An iridium carbene oxazoline complex was used to catalyze hydrogenations of trisubstituted alkenes to give terminal and internal 1,3-hydroxymethyl chirons. The products are accessible in all possible stereoisomeric forms. These hydrogenation do not require strongly coordinating functionalities on the substrate, and in some key cases, catalyst-rather than substrate-controlled stereoselectives are observed. It is hypothesized that these reactions would not be feasible using iridium or rhodium diphosphind complexes.

  DOI：

  10.1021/ja802909b
• 作为产物：
  描述：

  (R,E)-4-(tert-butyldiphenylsilyloxy)-2,6-dimethylhept-2-en-1-ol 在 C₃₂H₁₂BF₂₄^(1-)*C₃₇H₅₂IrN₃O⁽¹⁺⁾ 、 氢气 作用下， 以 二氯甲烷 为溶剂， 25.0 ℃ 、5.07 MPa 条件下， 反应 24.0h， 以84%的产率得到(2R,4R)-4-(tert-butyldiphenylsilyloxy)-2,6-dimethylheptan-1-ol
  参考文献：
  名称：

  Asymmetric Hydrogenation Approaches to Valuable, Acyclic 1,3-Hydroxymethyl Chirons

  摘要：

  An iridium carbene oxazoline complex was used to catalyze hydrogenations of trisubstituted alkenes to give terminal and internal 1,3-hydroxymethyl chirons. The products are accessible in all possible stereoisomeric forms. These hydrogenation do not require strongly coordinating functionalities on the substrate, and in some key cases, catalyst-rather than substrate-controlled stereoselectives are observed. It is hypothesized that these reactions would not be feasible using iridium or rhodium diphosphind complexes.

  DOI：

  10.1021/ja802909b

文献信息

• Asymmetric Hydrogenation Approaches to Valuable, Acyclic 1,3-Hydroxymethyl Chirons
  作者：Ye Zhu、Kevin Burgess

  DOI：10.1021/ja802909b

  日期：2008.7.1

  An iridium carbene oxazoline complex was used to catalyze hydrogenations of trisubstituted alkenes to give terminal and internal 1,3-hydroxymethyl chirons. The products are accessible in all possible stereoisomeric forms. These hydrogenation do not require strongly coordinating functionalities on the substrate, and in some key cases, catalyst-rather than substrate-controlled stereoselectives are observed. It is hypothesized that these reactions would not be feasible using iridium or rhodium diphosphind complexes.