1-(β-D-5-deoxy-arabinofuranosyl)-5-fluoro-1H-pyrimidine-2,4-dione | 69260-71-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: 1-(β-D-5-deoxy-arabinofuranosyl)-5-fluoro-1H-pyrimidine-2,4-dione
• 英文别名: 1-((2R,3S,4S,5R)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione；1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione
• CAS: 69260-71-5
• 化学式: C₉H₁₁FN₂O₅
• 分子量: 246.195
• InChiKey: ZWAOHEXOSAUJHY-YQHTUYAKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  99.1
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-[(2R,3S,4S,5R)-5-(chloromethyl)-3,4-dihydroxyoxolan-2-yl]-5-fluoropyrimidine-2,4-dione 、 三正丁基氢锡 生成 1-(β-D-5-deoxy-arabinofuranosyl)-5-fluoro-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  BERANEK, J.;HREBABECKY, H.;BROKES, J.

  摘要：

  DOI：

文献信息

• BERANEK, J.;HREBABECKY, H.;BROKES, J.
  作者：BERANEK, J.、HREBABECKY, H.、BROKES, J.

  DOI：——

  日期：——
• SYSTEM AND METHODS FOR IDENTIFYING INDIVIDUALS AT RISK FOR SYSTEMIC FLUOROPYRIMIDINE TOXICITY
  申请人：Cohen James M.

  公开号：US20080241068A1

  公开（公告）日：2008-10-02

  The present disclosure is related to methods and tests for identifying individuals at risk for systemic toxicity to a substance by administering a topical dose of the substance to the individual and observing any topical response to that substance. In particular, the present disclosure provides methods and tests for determining if an individual is at risk for fluoropyrimidine, such as 5-fluorouracil, toxicity or has a dihydropyrimidine dehydrogenase deficiency by exposing the skin of the individual to a dose of a fluoropyrimidine, such as 5-fluoruracil, using a transdermal skin patch. An inflammatory response of the skin indicates the risk of the individual to such toxicity or enzyme deficiency.