2-(4-Methyl-piperazino)-2-methyl-propionitril | 21404-83-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-Methyl-piperazino)-2-methyl-propionitril
• 英文别名: 2-methyl-2-(4-methyl-piperazin-1-yl)-propionitrile；2-Methyl-2-(4-methylpiperazin-1-yl)propanenitrile
• CAS: 21404-83-1
• 化学式: C₉H₁₇N₃
• mdl: MFCD06408031
• 分子量: 167.254
• InChiKey: SWRPBLUSCBYCPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  30.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PYRIMIDO-PYRIDAZINONE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Asana Biosciences, LLC

  公开号：US20160257691A1

  公开（公告）日：2016-09-08

  The present application provides novel pyrimido-pyridazinone compounds and methods for preparing and using these compounds. These compounds are useful in treating inflammation in patients by administering one or more of the compounds to a patient. In one embodiment, the novel pyrimido-pyridazinone compound is of Formula (I) and R 1 and R 2 are defined herein.

  本申请提供了新颖的嘧啶并吡啶嗪酮化合物以及制备和使用这些化合物的方法。这些化合物通过向患者施用一种或多种化合物来治疗患者的炎症。在一个实施例中，新颖的嘧啶并吡啶嗪酮化合物是公式（I）中的化合物，其中R1和R2在此定义。
• PYRIMIDO-PYRIDAZINONE COMPOUNDS AND USE THEREOF
  申请人：Asana BioSciences, LLC

  公开号：EP2748166B1

  公开（公告）日：2018-07-11
• USES OF PYRIMIDO-PYRIDAZINONES TO TREAT CANCER
  申请人：Asana Biosciences, LLC

  公开号：US20170157126A1

  公开（公告）日：2017-06-08

  Disclosed are methods of treating cancer, which include administering a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt or ester thereof, to a subject in need thereof. Also disclosed are methods of inhibiting growth and proliferation of cancer cells in vitro or in vivo, which include contacting the cells with an amount of the compound of formula (I) effective to inhibit the growth or proliferation of the cancer cells. Further disclosed are methods of inhibiting tumor growth, which include contacting the tumor with an amount of the compound of formula (I) effective to inhibit the growth of the tumor.
• US8729079B2
  申请人：——

  公开号：US8729079B2

  公开（公告）日：2014-05-20
• US9382277B2
  申请人：——

  公开号：US9382277B2

  公开（公告）日：2016-07-05