4-isopropylamino-piperidine dihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-isopropylamino-piperidine dihydrochloride
• 英文别名: N-propan-2-ylpiperidin-4-amine;hydrochloride
• 化学式: C₈H₁₈N₂*2ClH
• 分子量: 215.166
• InChiKey: AGAPXPFUQQNCCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.16
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-氟-3-(苯磺酰基)-喹啉 、 4-isopropylamino-piperidine dihydrochloride 在 N,N-二异丙基乙胺 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 0.5h， 生成 N-(1-methylethyl)-1-[3-(phenylsulfonyl)-8-quinolinyl]-4-piperidinamine
  参考文献：
  名称：

  [EN] 3-ARYLSULFONYL-QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS
  [FR] -QUINOLINES 3-ARYLSULFONYL3 UTILISEES COMME ANTAGONOSTES DU RECEPTEUR 5-HT6 POUR LE TRAITEMENT DE TROUBLES DU SYSTEME NERVEUX CENTRAL

  摘要：

  本发明涉及新型喹啉衍生物，如式（I）化合物，其具有对5-HT6受体的拮抗作用，以及这些化合物或其药物组合物在治疗中枢神经系统和其他疾病中的用途。

  公开号：

  WO2005113539A1

文献信息

• TRIAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：EP1628971A1

  公开（公告）日：2006-03-01
• [EN] TRIAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS<br/>[FR] DERIVES DE TRIAZOLE UTILISES COMME INHIBITEURS DU FACTOR XA
  申请人：AVENTIS PHARMA GMBH

  公开号：WO2004101555A1

  公开（公告）日：2004-11-25

  The present invention relates to compounds of the formulae (I) and (II), in which RO; R1; R3; Q; J1; J2; J3; J4; J5; V; G and M have the meanings indicated in the claims. The compounds of the formulae (I) and (II) are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formulae (I) and (II), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
• [EN] 3-ARYLSULFONYL-QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS<br/>[FR] -QUINOLINES 3-ARYLSULFONYL3 UTILISEES COMME ANTAGONOSTES DU RECEPTEUR 5-HT6 POUR LE TRAITEMENT DE TROUBLES DU SYSTEME NERVEUX CENTRAL
  申请人：GLAXO GROUP LTD

  公开号：WO2005113539A1

  公开（公告）日：2005-12-01

  The present invention relates to novel quinoline derivatives such as compounds of the formula (I) which have antagonist potency for the 5-HT6 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of CNS and other disorders.

  本发明涉及新型喹啉衍生物，如式（I）化合物，其具有对5-HT6受体的拮抗作用，以及这些化合物或其药物组合物在治疗中枢神经系统和其他疾病中的用途。