N-benzyl-6-(4-benzylpiperazin-1-yl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-benzyl-6-(4-benzylpiperazin-1-yl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• 英文别名: N-benzyl-6-(4-benzylpiperazin-1-yl)-1-methylpyrazolo[3,4-d]pyrimidin-4-amine
• 化学式: C₂₄H₂₇N₇
• mdl: MFCD07190497
• 分子量: 413.5
• InChiKey: FHUSATDKZQFXNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase
  申请人：Oncalis AG

  公开号：EP2025678A1

  公开（公告）日：2009-02-18

  The invention relates to pyrazolo[3,4-d]pyrimidine compounds of formual I and its salts wherein the substitents are as defined in the specification, their use for the treatment of protein kinase modulation responsive diseases or in the manufacture of pharmaceutical preparations useful in the treatment of said diseases, pharmaceutical preparations, especially useful against said diseases, comprising said compounds and a pharmaceutically acceptable carrier, said compounds for use in the treatment of the animal or human body, especially against said diseases, methods of treatment of the animal or human body comprising administering said compounds to an animal or human, and processes for the manufacture of said compounds.

  该发明涉及式I的吡唑并咪唑化合物及其盐，其中取代基如规范中所定义，其用于治疗蛋白激酶调节敏感疾病或用于制造在治疗该等疾病中有用的药物制剂，药物制剂，特别是针对该等疾病有用的药物制剂，包括该等化合物和药用可接受载体，该等化合物用于治疗动物或人体，尤其是针对该等疾病，包括将该等化合物给动物或人体进行治疗的方法，以及制造该等化合物的方法。