(2S)-1-methoxy-3-piperazin-1-ylpropan-2-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (2S)-1-methoxy-3-piperazin-1-ylpropan-2-ol
• 化学式: C₈H₁₈N₂O₂
• mdl: MFCD01016156
• 分子量: 174.24
• InChiKey: GPWPRZZSLQXWIQ-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] NOVEL COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF<br/>[FR] NOUVEAU COMPOSÉ, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
  申请人：DAEGU GYEONGBUK MEDICAL INNOVATION FOUND

  公开号：WO2021145729A1

  公开（公告）日：2021-07-22

  The present invention relates to a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing the same as an active ingredient. The method for preparing a biomaterial to which a compound represented by formula 2 is coupled, of the present invention, allows the compound represented by formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.

  本发明涉及一种制备具有选择性功能化酪氨酸的生物材料的方法，具有选择性功能化酪氨酸的生物材料，以及含有该生物材料作为活性成分的药物组合物。本发明的一种制备生物材料的方法，其中将由式2表示的化合物偶联到生物材料，使得该化合物能够选择性地偶联到酪氨酸，且在生物材料中的产率较高，酪氨酸位于水溶液表面，使得其与酪氨酸以外的氨基酸不发生偶联，当只有一个酪氨酸存在时，不会出现异质混合物，同时保持生物材料的固有活性，因此该化合物可以有效地用作含有生物材料药物的药物组合物的活性成分。此外，该方法可以选择性功能化酪氨酸，因此可以有效地用于生物材料中的酪氨酸功能化。
• [EN] FUSED BICYCLIC 2,4-DIAMINOPYRIMIDINE DERIVATIVES<br/>[FR] DÉRIVÉS DE 2,4-DIAMINOPYRIMIDINE BICYCLIQUES CONDENSÉS
  申请人：CEPHALON INC

  公开号：WO2015038868A1

  公开（公告）日：2015-03-19

  The present application discloses fused bicyclic compounds, having substituents as disclosed herein. These compounds demonstrate ALK and/or FAK inhibitory activity and may be used to treat disorders or conditions characterized by aberrant ALK and/or FAK activity in mammals, including humans. The present application further provides pharmaceutical compositions comprising at least one of these compounds together with at least one pharmaceutically acceptable excipient.

  本申请公开了融合的双环化合物，具有如本文所披露的取代基。这些化合物展示了ALK和/或FAK抑制活性，并可用于治疗哺乳动物，包括人类中由异常的ALK和/或FAK活性所特征的疾病或症状。本申请还提供了包含至少一种这些化合物和至少一种药用可接受的赋形剂的药物组合物。