N-acetylspiro(1,3-benzodioxane-2,4'-piperidine)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-acetylspiro(1,3-benzodioxane-2,4'-piperidine)
• 英文别名: 1-spiro[4H-1,3-benzodioxine-2,4'-piperidine]-1'-ylethanone
• 化学式: C₁₄H₁₇NO₃
• 分子量: 247.294
• InChiKey: AUNLNRBXWGZLEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-acetylspiro(1,3-benzodioxane-2,4'-piperidine) 在 氢氧化钾 作用下， 以 乙醇 、 水 为溶剂， 反应 12.0h， 以98%的产率得到4H-spiro[1,3-benzodioxine-2,4'-piperidine]
  参考文献：
  名称：

  Novel tricyclic spiropiperidines. Synthesis and adrenergic activity of spiro[1,3-benzodioxolopiperidines] and spiro[1,3-benzodioxanepiperidines]

  摘要：

  The synthesis of new series of spiropiperidines is reported. Some of these compounds showed interesting adrenergic activity. The biological activities of the new compounds were evaluated on-guinea pig atria (beta 1), guinea-pig trachea (beta 2) and rat vas deferens (alpha). Compounds 6a, 6c and 6f showed activity comparable to propranolol, in spite of being tertiary amines.

  DOI：

  10.1016/s0223-5234(97)89851-0
• 作为产物：
  描述：

  N-乙酰基-4-哌啶酮 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 生成 N-acetylspiro(1,3-benzodioxane-2,4'-piperidine)
  参考文献：
  名称：

  Novel tricyclic spiropiperidines. Synthesis and adrenergic activity of spiro[1,3-benzodioxolopiperidines] and spiro[1,3-benzodioxanepiperidines]

  摘要：

  The synthesis of new series of spiropiperidines is reported. Some of these compounds showed interesting adrenergic activity. The biological activities of the new compounds were evaluated on-guinea pig atria (beta 1), guinea-pig trachea (beta 2) and rat vas deferens (alpha). Compounds 6a, 6c and 6f showed activity comparable to propranolol, in spite of being tertiary amines.

  DOI：

  10.1016/s0223-5234(97)89851-0

文献信息

• Novel tricyclic spiropiperidines. Synthesis and adrenergic activity of spiro[1,3-benzodioxolopiperidines] and spiro[1,3-benzodioxanepiperidines]
  作者：MD Pujol、G Rosell、G Guillaumet

  DOI：10.1016/s0223-5234(97)89851-0

  日期：1996.1

  The synthesis of new series of spiropiperidines is reported. Some of these compounds showed interesting adrenergic activity. The biological activities of the new compounds were evaluated on-guinea pig atria (beta 1), guinea-pig trachea (beta 2) and rat vas deferens (alpha). Compounds 6a, 6c and 6f showed activity comparable to propranolol, in spite of being tertiary amines.