(3R)-3-ethyl-1-propan-2-ylpiperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (3R)-3-ethyl-1-propan-2-ylpiperazine
• 化学式: C₉H₂₀N₂
• 分子量: 156.27
• InChiKey: FDCAQXFCSLLAGV-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PYRIMIDINES AS SODIUM CHANNEL BLOCKERS
  申请人：PURDUE PHARMA L.P.

  公开号：US20140303139A1

  公开（公告）日：2014-10-09

  The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A 1 , X, A 2 , W 1 , W 2 , E, Z, and R 4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

  本公开提供式（I）的取代嘧啶化合物，以及其药学上可接受的盐、前药和溶剂化物，其中A1、X、A2、W1、W2、E、Z和R4的定义如规范中所述。本公开还涉及使用式（I）的化合物治疗对钠通道阻滞响应的疾病。本公开的化合物特别适用于治疗疼痛。
• PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL FOR TREATING SPINAL MUSCULAR ATROPHY
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3663296A1

  公开（公告）日：2020-06-10

  The present invention provides compounds of formula (I) wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

  本发明提供了式 (I) 的化合物 其中 A、R1、R2 和 R3 如本文所述，以及其药学上可接受的盐类。此外，本发明还涉及式 (I) 化合物的制造、包含它们的药物组合物及其作为药物的用途。
• Compounds for treating spinal muscular atrophy
  申请人：Hoffmann-La Roche Inc.

  公开号：US10208067B2

  公开（公告）日：2019-02-19

  The present invention provides compounds of formula (I) wherein A, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

  本发明提供了式 (I) 的化合物 其中 A、X、Y、R1 和 R2 如本文所述，以及其药学上可接受的盐类。此外，本发明还涉及式 (I) 化合物的制造、包含它们的药物组合物及其作为药物的用途。
• COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3143025B1

  公开（公告）日：2019-10-09
• N-(IMIDAZO[1,2-A]PYRAZIN-6-YL)-BENZAMIDE COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3160967B1

  公开（公告）日：2019-05-08