1-(3-Chlorophenyl)-4-(1,3,5-trimethylpyrazol-4-yl)sulfonylpiperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(3-Chlorophenyl)-4-(1,3,5-trimethylpyrazol-4-yl)sulfonylpiperazine
• 化学式: C₁₆H₂₁ClN₄O₂S
• 分子量: 368.9
• InChiKey: YIRIKDUQYDESQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  66.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS AND MESENCHYMAL CANCER TYPES
  申请人：The Scripps Research Institute

  公开号：US20210196713A1

  公开（公告）日：2021-07-01

  The present disclosure provides compounds, their pharmaceutical compositions, and methods of their use for treating mesenchymally-derived or mesenchymally transformed cancers, such as breast cancers and sarcomas, and for treating diseases or disorders that are characterized by the expression of vimentin.