(3R,5S)-3,5-dimethyl-1-(1-propan-2-ylpiperidin-4-yl)piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (3R,5S)-3,5-dimethyl-1-(1-propan-2-ylpiperidin-4-yl)piperazine
• 化学式: C₁₄H₂₉N₃
• 分子量: 239.4
• InChiKey: DUDAVZWZWXFNDL-BETUJISGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Aminopyrimidine compound, preparation method therefor and use thereof
  申请人：BEIJING ADAMADLE BIOTECHNOLOGY LIMITED LIABILITY COMPANY

  公开号：US11352352B2

  公开（公告）日：2022-06-07

  The present invention relates to an aminopyrimidine compound, a preparation method therefor and use thereof. The aminopyrimidine compound has the structure as shown in formula I: the compound is an inhibitor of an epidermal growth factor receptor (EGFR) kinase. The present invention also relates to a pharmaceutical composition containing the compounds, a method for preparing same and the use of same in preparation of anti-tumor drugs.

  本发明涉及一种氨基嘧啶化合物、其制备方法及其用途。氨基嘧啶化合物的结构如式 I 所示： 该化合物是表皮生长因子受体（EGFR）激酶的抑制剂。本发明还涉及一种含有上述化合物的药物组合物、制备方法以及在制备抗肿瘤药物中的应用。
• AMINOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：BEIJING ADAMADLE BIOTECHNOLOGY LIMITED LIABILITY COMPANY

  公开号：US20200087296A1

  公开（公告）日：2020-03-19

  The present invention relates to an aminopyrimidine compound, a preparation method therefor and use thereof. The aminopyrimidine compound has the structure as shown in formula I: the compound is an inhibitor of an epidermal growth factor receptor (EGFR) kinase. The present invention also relates to a pharmaceutical composition containing the compounds, a method for preparing same and the use of same in preparation of anti-tumor drugs.