(1R,3S)-3-[(4-methylpiperazin-1-yl)methyl]cyclohexan-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (1R,3S)-3-[(4-methylpiperazin-1-yl)methyl]cyclohexan-1-amine
• 化学式: C₁₂H₂₅N₃
• 分子量: 211.35
• InChiKey: OVEUEOILIRUAOO-NWDGAFQWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)
  申请人：Syros Pharmaceuticals, Inc.

  公开号：US20180208578A1

  公开（公告）日：2018-07-26

  The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.