3-Bromo-5-[3-(3-bromo-5-hydroxy-4-methylphenyl)-1,1-dioxo-2,1lambda6-benzoxathiol-3-yl]-2-methylphenol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 3-Bromo-5-[3-(3-bromo-5-hydroxy-4-methylphenyl)-1,1-dioxo-2,1lambda6-benzoxathiol-3-yl]-2-methylphenol
• 英文别名: 3-bromo-5-[3-(3-bromo-5-hydroxy-4-methylphenyl)-1,1-dioxo-2,1λ6-benzoxathiol-3-yl]-2-methylphenol
• 化学式: C₂₁H₁₆Br₂O₅S
• 分子量: 540.2
• InChiKey: BPZRGCCIJYGLJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  92.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Synthesis and separation of optically active isomers of erythromycin and their biological actions
  申请人：——

  公开号：US20040067898A1

  公开（公告）日：2004-04-08

  The present invention provides methods for purifying and using optically active isomers of erythromycin as well as compositions comprising such optically active isomers. Such optically active isomers having desired actions as an antibiotic substantially separable from undesirable effects on GI motility and the cardiac potassium channels such that the cardiac action potential is not prolonged and the QT interval on the surface EKG (electrocardiogram) is not increased, such that the erythromycin can be useful for more effective therapy of systemic infections. Also disclosed are methods for assaying the levels of such isomers present in the biological fluids.

  本发明提供了纯化和使用光学活性异构体红霉素的方法，以及包含这些光学活性异构体的组合物。这些光学活性异构体具有作为抗生素所需的作用，且与胃肠道动力和心脏钾通道的不良影响明显分离，从而心脏动作电位不会延长，表面心电图（电心图）上的QT间期不会增加，因此红霉素可以用于更有效地治疗全身性感染。还公开了检测生物体液中这些异构体水平的方法。
• INDICATORS FOR DETECTING THE PRESENCE OF METABOLIC BYPRODUCTS FROM MICROORGANISMS
  申请人：Gorski Joel R.

  公开号：US20100196636A1

  公开（公告）日：2010-08-05

  Polymeric indicator films and pH indicating wraps are provided for visually monitoring, detecting, and/or determining the presence of metabolic byproducts from harmful or potentially harmful microorganisms. Also provided are methods of use and preparation of the polymeric indicator films.

  提供用于视觉监测、检测和/或确定有害或潜在有害微生物代谢产物存在的聚合物指示膜和pH指示包装。还提供了聚合物指示膜的使用和制备方法。
• INDICATORS FOR DETECTING THE PRESENCE OF METABOLIC BY-PRODUCTS FROM MICROORGANISMS
  申请人：Gorski Joel R.

  公开号：US20120316408A1

  公开（公告）日：2012-12-13

  pH indicator compositions, solutions and suspensions and pH indicating food storage devices, medical devices and components thereof are provided for visually monitoring, detecting, and/or determining the presence of metabolic by-products from harmful or potentially harmful microorganisms. Also provided are methods of use and preparation of the pH indicator compositions, solutions and suspensions.

  提供了用于视觉监测、检测和/或确定有害或潜在有害微生物代谢产物存在的pH指示剂组合物、溶液和悬浮液以及pH指示食品储存设备、医疗设备和其组件。还提供了pH指示剂组合物、溶液和悬浮液的使用和制备方法。
• Silicon vesicles and entrapment
  申请人：DOW CORNING CORPORATION

  公开号：EP0672410A1

  公开（公告）日：1995-09-20

  A method of entrapping a water-soluble substance in vesicles formed from a siloxane surfactant is carried out by dissolving the substance to be entrapped in water, adding a siloxane surfactant, mildly agitating the mixture and removing excess of water and substance. Further, water-insoluble substances can be entrapped in the vesicles by dissolving the substance to be entrapped in the siloxane surfactant and mildly agitating the substance and the siloxane surfactant. Suitable siloxane surfactants are R-[Si(Me)₂O]₁₄-Si(Me)₂-R in which R is -(CH₂)₃(OCH₂CH₂)₇OH, R-[Si(Me)₂O]₁₄-Si(Me)₂-R in which R is -(CH₂)₃(OCH₂CH₂)₁₂OH, Me₃SiO[Si(Me)₂O]₂₂-[SiMeRO]₂-SiMe₃ in which R is -(CH₂)₃(OCH₂CH₂)₁₂OH and Me₃SiO[Si(Me)₂O]₁₀₃-[SiMeRO]₁₀-SiMe₃ in which R is -(CH₂)₃(OCH₂CH₂)₁₂OH.

  在硅氧烷表面活性剂形成的囊泡中夹带水溶性物质的方法是将待夹带的物质溶解在水中，加入硅氧烷表面活性剂，轻度搅拌混合物并去除多余的水和物质。此外，水不溶性物质也可以通过将待夹带物质溶解在硅氧烷表面活性剂中并轻度搅拌该物质和硅氧烷表面活性剂而被夹带到囊泡中。合适的硅氧烷表面活性剂有 R-[Si(Me)₂O]₁₄-Si(Me)₂-R，其中 R 是-(CH₂)₃(OCH₂CH₂)₇OH，R-[Si(Me)₂O]₁₄-Si(Me)₂-R，其中 R 是-(CH₂)₃(OCH₂CH₂)₁₂OH、Me₃SiO[Si(Me)₂O]₂₂-[SiMeRO]₂-SiMe₃ 其中 R 是 -(CH₂)₃(OCH₂CH₂)₁₂OH 和 Me₃SiO[Si(Me)₂O]₁₀₃-[SiMeRO]₁₀-SiMe₃ 其中 R 是 -(CH₂)₃(OCH₂CH₂)₁₂OH.
• Siloxane MQ resin vesicles and entrapment
  申请人：DOW CORNING CORPORATION

  公开号：EP0724876A2

  公开（公告）日：1996-08-07

  A method of entrapping a water-soluble substance in vesicles formed from a surface active siloxane is carried out by dissolving the substance to be entrapped in water, adding the surface active siloxane, mildly agitating the mixture and removing excess water and substance. Water-insoluble substances are entrapped in the vesicles by dissolving the substance to be entrapped in the surface active siloxane and mildly agitating the substance and the siloxane. The surface active siloxanes essentially consist of tetravalent SiO2 units and monovalent R3SiO1/2 and R'R2SiO1/2 units. The ratio of monovalent units to tetravalent units is from 0.4:1 to 2:1 and from 40 to 90% of all monovalent units are R'R2SiO1/2 units. R is a monovalent hydrocarbon group with up to eight carbon atoms and R' is a polyoxyalkylene group.

  一种将水溶性物质夹带在由表面活性硅氧烷形成的囊泡中的方法是将待夹带物质溶解在水中，加入表面活性硅氧烷，轻度搅拌混合物并除去多余的水和物质。将水不溶性物质溶解在表面活性硅氧烷中，并轻度搅拌该物质和硅氧烷，即可将其包裹在囊泡中。表面活性硅氧烷主要由四价 SiO2 单元和一价 R3SiO1/2 和 R'R2SiO1/2 单元组成。单价单元与四价单元的比例为 0.4:1 至 2:1，40% 至 90% 的单价单元为 R'R2SiO1/2 单元。R 是具有最多八个碳原子的一价烃基，R'是聚氧亚烷基。