(1R,5S)-3β-phenyl-2β-n-propyltropane

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: (1R,5S)-3β-phenyl-2β-n-propyltropane
• 英文别名: (1R,5S)-2β-n-propyl-3β-phenyltropane；(1R,2S,3S,5S)-8-methyl-3-phenyl-2-propyl-8-azabicyclo[3.2.1]octane
• 化学式: C₁₇H₂₅N
• 分子量: 243.392
• InChiKey: ZWPCJQABQGIZIQ-MWDXBVQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  脱水芽子碱甲基酯甲磺酸盐 在 palladium on activated charcoal 正丁基锂 、 草酰氯 、 氢气 、 二异丁基氢化铝 、 二甲基亚砜 作用下， 以 乙醚 、 乙醇 、 正己烷 、 二氯甲烷 、 甲苯 为溶剂， -40.0~25.0 ℃ 、275.79 kPa 条件下， 反应 21.5h， 生成 (1R,5S)-3β-phenyl-2β-n-propyltropane
  参考文献：
  名称：

  Chemistry and Biology of the 2.beta.-Alkyl-3.beta.-phenyl Analogs of Cocaine: Subnanomolar Affinity Ligands That Suggest a New Pharmacophore Model at the C-2 Position

  摘要：

  A series of 2 beta-alkyl-3 beta-phenyltropanes (i.e., the 2 beta-alkyl analogues of the WIN series) were prepared as analogues of cocaine and tested for their ability to displace [H-3]mazindol binding and to inhibit high-affinity dopamine uptake into striatal nerve endings (synaptosomes). These 2 beta-alkyl analogues were readily prepared in optically pure form starting from cocaine by proceeding through the 2 beta-phenyl-bearing aldehyde 6 as a key intermediate. Wittig reaction of 6 with the appropriate phosphorane and hydrogenation delivered the final products. Ah new compounds with the exception of 8e were found to exhibit nanomolar or subnanomolar affinity for the cocaine binding site in the rat striatum. These results are in apparent opposition to the binding model previously proposed which suggests a hydrogen bond donor-acceptor interaction to be present in the vicinity of the C-2 substituent. Taken together with our previous reports and recent findings from other laboratories, we suggest a new pharmacophore model in which 2 beta-substituents lacking H-bond accepters enhance affinity to the binding site through hydrophobic interactions. The new SAR data contained herein may be relevant to the design of possible cocaine antagonists.

  DOI：

  10.1021/jm00016a012

文献信息

• Tropane derivatives and method for their synthesis
  申请人：Georgetown University

  公开号：US06350758B1

  公开（公告）日：2002-02-26

  A compound of formula (I) wherein R1-R6 have any of the values defined in the specification are described, as well as pharmaceutical compositions comprising a compound of formula (I), and methods for preparing and using compounds of formula (I) are described.

  公式（I）的化合物，其中R1-R6具有规范中定义的任何值，以及包括公式（I）的化合物的药物组合物，以及描述了制备和使用公式（I）化合物的方法。
• Synthesis and Biological Properties of New 2β-Alkyl- and 2β-Aryl-3-(substituted phenyl)tropane Derivatives:  Stereochemical Effect of C-3 on Affinity and Selectivity for Neuronal Dopamine and Serotonin Transporters
  作者：Alan P. Kozikowski、Gian Luca Araldi、K. R. C. Prakash、Mei Zhang、Kenneth M. Johnson

  DOI：10.1021/jm9802564

  日期：1998.12.1

  present work is a 2, 3-diaryltropane 22 in a boat conformation that is highly selective (69-fold) for the DAT over the 5HTT. The ability to prepare this compound as well as related structures by our oxidopyridinium betaine-based dipolar cycloaddition strategy further underscores the versatility of this particular chemical approach to the preparation of diverse tropane analogues. The use of the optically

  在努力确定可能充当可卡因拮抗剂或可卡因部分激动剂的分子的过程中，我们参与了通过结构上的战略性修饰来进一步阐明可卡因与多巴胺转运蛋白（DAT）结合的性质的努力。在取代基位于托环环的2位的情况下，研究表明转运蛋白能够容纳多种结构的基团，包括酯，酮，烷基，烯基，杂环和芳基取代基，而不会损失DAT绑定亲和力。在本研究中，我们报告了有关DAT容纳WIN型结构的能力的结果，该结构在2位具有烷基或芳基，并且采用了环烷的椅子或船形。而且，我们讨论了这些化合物的立体化学对DAT相对于血清素转运蛋白（5HTT）的选择性的影响。此外，我们指出了在进行转运蛋白选择性的比较时，使用Ki值而不是IC50值的重要性。在本研究中鉴定出的最有趣的化合物之一是船形的2，3-二芳基托烷22，它对DAT的选择性比5HTT高（69倍）。通过我们基于氧化吡啶鎓甜菜碱的偶极环加成策略制备该化合物及相关结构的能力进一步强调了这种特殊化学
• Araldi, Gian Luca; Prakash; George, Clifford, Chemical Communications, 1997, # 19, p. 1875 - 1876
  作者：Araldi, Gian Luca、Prakash、George, Clifford、Kozikowski, Alan P.

  DOI：——

  日期：——
• US6350758B1
  申请人：——

  公开号：US6350758B1

  公开（公告）日：2002-02-26
• Chemistry and Biology of the 2.beta.-Alkyl-3.beta.-phenyl Analogs of Cocaine: Subnanomolar Affinity Ligands That Suggest a New Pharmacophore Model at the C-2 Position
  作者：Alan P. Kozikowski、M. K. Eddine Saiah、Kenneth M. Johnson、John S. Bergmann

  DOI：10.1021/jm00016a012

  日期：1995.8

  A series of 2 beta-alkyl-3 beta-phenyltropanes (i.e., the 2 beta-alkyl analogues of the WIN series) were prepared as analogues of cocaine and tested for their ability to displace [H-3]mazindol binding and to inhibit high-affinity dopamine uptake into striatal nerve endings (synaptosomes). These 2 beta-alkyl analogues were readily prepared in optically pure form starting from cocaine by proceeding through the 2 beta-phenyl-bearing aldehyde 6 as a key intermediate. Wittig reaction of 6 with the appropriate phosphorane and hydrogenation delivered the final products. Ah new compounds with the exception of 8e were found to exhibit nanomolar or subnanomolar affinity for the cocaine binding site in the rat striatum. These results are in apparent opposition to the binding model previously proposed which suggests a hydrogen bond donor-acceptor interaction to be present in the vicinity of the C-2 substituent. Taken together with our previous reports and recent findings from other laboratories, we suggest a new pharmacophore model in which 2 beta-substituents lacking H-bond accepters enhance affinity to the binding site through hydrophobic interactions. The new SAR data contained herein may be relevant to the design of possible cocaine antagonists.