tert-butyl 4-[(R)-amino(phenyl)methyl]piperidine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl 4-[(R)-amino(phenyl)methyl]piperidine-1-carboxylate
• 化学式: C₁₇H₂₆N₂O₂
• 分子量: 290.4
• InChiKey: WTARUKRBKMNNAD-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl 4-[(R)-amino(phenyl)methyl]piperidine-1-carboxylate 在 盐酸 、 4-二甲氨基吡啶 、 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 N-[(R)-phenyl(piperidin-4-yl)methyl]-6-propan-2-yloxypyridine-3-sulfonamide
  参考文献：
  名称：

  [EN] AROMATIC COMPOUNDS FOR USE AS PROTEIN PHOSPHATASE 2A (PP2A) MODULATORS
  [FR] COMPOSÉS AROMATIQUES DESTINÉS À ÊTRE UTILISÉS COMME MODULATEURS DE LA PROTÉINE PHOSPHATASE 2A (PP2A)

  摘要：

  The present disclosure relates to compounds of Formula (I) which modulate the activity of protein phosphatase 2A (PP2A). The compounds of the present disclosure are useful in treating, preventing, and/or ameliorating cancer, diabetes, autoimmune disease, solid organ transplant rejection, graft vs. host disease, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease, abdominal aortic aneurysm, chronic liver disease, heart failure, neurodegenerative disease, and cardiac hypertrophy.

  公开号：

  WO2024028808A1
• 作为产物：
  描述：

  tert-butyl (R,E)-4-(((tert-butylsulfinyl)imino)methyl)piperidine-1-carboxylate 在 盐酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 为溶剂， 反应 15.0h， 生成 tert-butyl 4-[(R)-amino(phenyl)methyl]piperidine-1-carboxylate
  参考文献：
  名称：

  [EN] AROMATIC COMPOUNDS FOR USE AS PROTEIN PHOSPHATASE 2A (PP2A) MODULATORS
  [FR] COMPOSÉS AROMATIQUES DESTINÉS À ÊTRE UTILISÉS COMME MODULATEURS DE LA PROTÉINE PHOSPHATASE 2A (PP2A)

  摘要：

  The present disclosure relates to compounds of Formula (I) which modulate the activity of protein phosphatase 2A (PP2A). The compounds of the present disclosure are useful in treating, preventing, and/or ameliorating cancer, diabetes, autoimmune disease, solid organ transplant rejection, graft vs. host disease, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease, abdominal aortic aneurysm, chronic liver disease, heart failure, neurodegenerative disease, and cardiac hypertrophy.

  公开号：

  WO2024028808A1

文献信息

• [EN] AROMATIC COMPOUNDS FOR USE AS PROTEIN PHOSPHATASE 2A (PP2A) MODULATORS<br/>[FR] COMPOSÉS AROMATIQUES DESTINÉS À ÊTRE UTILISÉS COMME MODULATEURS DE LA PROTÉINE PHOSPHATASE 2A (PP2A)
  申请人：[en]RAPPTA THERAPEUTICS OY

  公开号：WO2024028808A1

  公开（公告）日：2024-02-08

  The present disclosure relates to compounds of Formula (I) which modulate the activity of protein phosphatase 2A (PP2A). The compounds of the present disclosure are useful in treating, preventing, and/or ameliorating cancer, diabetes, autoimmune disease, solid organ transplant rejection, graft vs. host disease, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease, abdominal aortic aneurysm, chronic liver disease, heart failure, neurodegenerative disease, and cardiac hypertrophy.