(4R-cis)-1-[[6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetyl]piperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (4R-cis)-1-[[6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetyl]piperidine
• 英文别名: 2-[6-(2-Aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]-1-piperidin-1-ylethanone
• 化学式: C₁₅H₂₈N₂O₃
• 分子量: 284.399
• InChiKey: PSVCPLUEKMFRRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  64.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PROCESSES FOR PREPARING AMINE SALTS OF SILDENAFIL-ANALOGUES AND USE THEREOF
  申请人：Chen Ing-Jun

  公开号：US20120108604A1

  公开（公告）日：2012-05-03

  A series of amine salts including a structure of formula (I) and formula (III) have provided. In formula I or formula (III), R 1 , R a and RX are as defined in the specification. The amine complex salts disclosed in the present invention are characterized in a pro-drug active form and various pharmaceutical function.

  提供了一系列包括公式(I)和公式(III)结构的胺盐。在公式I或公式(III)中，R1、Ra和RX如说明书中所定义。本发明公开的胺络合盐具有前药活性形式和多种药理功能。
• Processes for preparing calcium salt forms of statins
  申请人：Niddam-Hildesheim Valerie

  公开号：US20050197501A1

  公开（公告）日：2005-09-08

  Processes for preparing a calcium salt of a statin from an ester derivative or protected ester derivative of the statin by using calcium hydroxide are provided. The ester or protected ester derivative is contacted with calcium hydroxide to obtain the calcium salt. Preferred statins are rosuvastatin, pitavastatin and atorvastatin, simvastatin and lovastatin. In processes beginning with a protected statin ester derivative, the protecting group is hydrolyzed during salt formation by contact with calcium hydroxide, or is contacted with an acid catalyst followed by contact with calcium hydroxide.

  本发明提供了一种使用氢氧化钙从他汀的酯衍生物或保护酯衍生物制备钙盐的过程。将酯或保护酯衍生物与氢氧化钙接触，以获得钙盐。首选他汀是罗伊司他、匹伐他汀和阿托伐他汀、辛伐他汀和洛伐他汀。在以保护的他汀酯衍生物开始的过程中，保护基在与氢氧化钙接触时水解，在盐形成过程中，或与酸催化剂接触后再与氢氧化钙接触。
• PROCESSES FOR PREPARING PIPERAZINIUM SALTS OF KMUP AND USE THEREOF
  申请人：Chen Ing-Jun

  公开号：US20110136767A1

  公开（公告）日：2011-06-09

  A series of monoquarternary piperazium salts including a structure of a formula I or II are provided. In formula I or II, R 1 , R a , and RX are as defined in the specification. The monoquarternary piperazium salt of KMUP or piperazine disclosed in the present invention is characterized by being presented in a pro-drug form and having various pharmaceutical functions.

  本发明提供了一系列单季铵哌嗪盐，其中包括公式I或II的结构。在公式I或II中，R1、Ra和RX如规范中所定义。本发明披露的KMUP或哌嗪的单季铵盐具有以前药物形式呈现并具有各种药物功能的特点。
• NOVEL PROCESS FOR $i(TRANS)-6- 2-(SUBSTITUTED-PYRROL-1-YL)ALKYL]PYRAN-2-ONE INHIBITORS OF CHOLESTEROL SYNTHESIS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0687263A1

  公开（公告）日：1995-12-20
• PROCESS FOR PREPARING (TRANS)-6- [2-(SUBSTITUTED-PYRROL-1-YL)ALKYL]PYRAN-2-ONE INHIBITORS OF CHOLESTEROL SYNTHESIS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0687263B1

  公开（公告）日：1997-07-30