3-allyl-6-ethyl-6-(3-nitrophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-allyl-6-ethyl-6-(3-nitrophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione
• 英文别名: 6-ethyl-6-(3-nitrophenyl)-3-prop-2-enyl-3-azabicyclo[3.1.0]hexane-2,4-dione
• 化学式: C₁₆H₁₆N₂O₄
• 分子量: 300.314
• InChiKey: IJLFGBIQLBOPMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  83.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-allyl-6-ethyl-6-(3-nitrophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione 、 铁粉 在 无水氯化钙 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 以65%的产率得到3-allyl-6-(3-aminophenyl)-6-ethyl-3-azabicyclo[3.1.0]hexane-2,4-dione
  参考文献：
  名称：

  3-azabicyclo[3.1.0]hexane derivatives useful in therapy

  摘要：

  公式I的化合物，其中取代基如本文所定义，并且其药用或兽医学上可接受的衍生物或前药，在药用和兽医学上具有用途，特别是它们结合到阿片受体（例如mu、kappa和delta阿片受体）。它们可能对通过阿片受体调节的疾病或情况具有用处，例如肠易激综合征；便秘；恶心；呕吐；瘙痒性皮肤病，如过敏性皮炎和特应性皮炎；进食障碍；阿片过量；抑郁症；吸烟和酒精成瘾；性功能障碍；休克；中风；脊柱损伤；头部创伤。

  公开号：

  US20020025948A1

文献信息

• 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
  申请人：——

  公开号：US20020025948A1

  公开（公告）日：2002-02-28

  Compounds of formula I, 1 where the substituents are as defined herein, and the pharmaceutically or veterinarily acceptable derivatives or prodrugs thereof, are pharmaceutically and veterinarily useful, in particular they bind to opiate receptors (e.g. mu, kappa and delta opioid receptors). They are likely to be useful in the treatment of diseases or conditions modulated by opiate receptors, for example irritable bowel syndrome; constipation; nausea; vomiting; pruritic dermatoses, such as allergic dermatitis and atopy; eating disorders; opiate overdoses; depression; smoking and alcohol addiction; sexual dysfunction; shock; stroke; spinal damage; and head trauma.

  公式I的化合物，其中取代基如本文所定义，并且其药用或兽医学上可接受的衍生物或前药，在药用和兽医学上具有用途，特别是它们结合到阿片受体（例如mu、kappa和delta阿片受体）。它们可能对通过阿片受体调节的疾病或情况具有用处，例如肠易激综合征；便秘；恶心；呕吐；瘙痒性皮肤病，如过敏性皮炎和特应性皮炎；进食障碍；阿片过量；抑郁症；吸烟和酒精成瘾；性功能障碍；休克；中风；脊柱损伤；头部创伤。
• 3-AZABICYCLO[3.1.0]HEXANE DERIVATIVES HAVING OPIOID RECEPTOR AFFINITY
  申请人：PFIZER INC.

  公开号：EP1292574A1

  公开（公告）日：2003-03-19
• [EN] 3-AZABICYCLO (3.1.0) HEXANE DERIVATIVES HAVING OPIOID RECEPTOR AFFINITY<br/>[FR] DERIVES 3-AZABICYCLO[3.1.0] HEXANE AYANT UNE AFFINITE POUR LE RECEPTEUR OPIOIDE
  申请人：PFIZER LTD

  公开号：WO2001098267A1

  公开（公告）日：2001-12-27

  Compounds of formula (I), where the substituents are as defined herein, and the pharmaceutically or veterinarily acceptable derivatives or prodrugs thereof, are pharmaceutically and veterinarily useful, in particular they bind to opiate receptors (e.g. mu, kappa and delta opioid receptors). They are likely to be useful in the treatment of diseases or conditions modulated by opiate receptors, for example irritable bowel syndrome; constipation; nausea; vomiting; pruritic dermatoses, such as allergic dermatitis and atopy; eating disorders; opiate overdoses; depression; smoking and alcohol addiction; sexual dysfunction; shock; stroke; spinal damage; and head trauma.
• 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy
  申请人：——

  公开号：US20030207876A1

  公开（公告）日：2003-11-06

  Compounds of formula I, 1 where the substituents are as defined herein, and the pharmaceutically or veterinarily acceptable derivatives or prodrugs thereof, are pharmaceutically and veterinarily useful, in particular they bind to opiate receptors (e.g. mu, kappa and delta opioid receptors). They are likely to be useful in the treatment of diseases or conditions modulated by opiate receptors, for example irritable bowel syndrome; constipation; nausea; vomiting; pruritic dermatoses, such as allergic dermatitis and atopy; eating disorders; opiate overdoses; depression; smoking and alcohol addiction; sexual dysfunction; shock; stroke; spinal damage; and head trauma.

  公式I的化合物，其中取代基如本文所定义，并且其药用或兽医学上可接受的衍生物或前药，在药用和兽医学上具有用途，特别是它们结合到阿片受体（例如mu、kappa和delta阿片受体）。它们可能在治疗由阿片受体调节的疾病或症状中有用，例如肠易激综合征；便秘；恶心；呕吐；瘙痒性皮肤病，如过敏性皮炎和特应性皮炎；进食障碍；阿片过量；抑郁症；吸烟和酒精成瘾；性功能障碍；休克；中风；脊柱损伤；头部创伤。