2,4-Bis(4-benzylpiperazin-1-yl)pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2,4-Bis(4-benzylpiperazin-1-yl)pyrimidine
• 化学式: C₂₆H₃₂N₆
• 分子量: 428.6
• InChiKey: JLSZTAWUYCPTMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• New Toll-Like Receptor 9 Antagonists
  申请人：Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

  公开号：EP3072891A1

  公开（公告）日：2016-09-28

  The present invention relates to a compound or a pharmaceutically acceptable salt thereof or a solvate thereof or a pharmaceutical composition comprising said compound, a process for obtaining or screening for a toll-like receptor 9 (TLR9) antagonist and a toll-like receptor 9 (TLR9) antagonist or a pharmaceutically acceptable salt thereof or a solvate thereof, preferably being obtainable thereby.

  本发明涉及一种化合物或其药学上可接受的盐或其溶液或包含所述化合物的药物组合物，一种获得或筛选toll样受体9（TLR9）拮抗剂的工艺，以及一种toll样受体9（TLR9）拮抗剂或其药学上可接受的盐或其溶液，优选由此获得。
• NEW TOLL-LIKE RECEPTOR 9 ANTAGONISTS
  申请人：FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

  公开号：US20190106418A1

  公开（公告）日：2019-04-11

  The present invention relates to a compound or a pharmaceutically acceptable salt thereof or a solvate thereof or a pharmaceutical composition comprising said compound, a process for obtaining or screening for a toll-like receptor 9 (TLR9) antagonist and a toll-like receptor 9 (TLR9) antagonist or a pharmaceutically acceptable salt thereof or a solvate thereof, preferably being obtainable thereby.