2-(2-chlorophenoxy)-N-[2-(4-ethylpiperazin-1-yl)phenyl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(2-chlorophenoxy)-N-[2-(4-ethylpiperazin-1-yl)phenyl]acetamide
• 化学式: C₂₀H₂₄ClN₃O₂
• 分子量: 373.9
• InChiKey: HZYCVLKRRVRDHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  44.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BONE DISEASES
  申请人：INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY

  公开号：US20220274935A1

  公开（公告）日：2022-09-01

  A composition according to an embodiment of the present disclosure includes a compound represented by Formula 1. The composition may inhibit osteoclast differentiation and/or formation and exhibit excellent prophylactic or therapeutic effects on various bone diseases including periodontitis and the like. A method for treating a bone disease caused by hyperdifferentiation of osteoclasts according to an embodiment of the present disclosure includes administering to a subject in need thereof the composition.