(E)-1-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-3-(5-methylthiophen-2-yl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (E)-1-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-3-(5-methylthiophen-2-yl)prop-2-en-1-one
• 化学式: C₁₉H₂₁ClN₂OS
• 分子量: 360.9
• InChiKey: XDJGDYPOFOTHRT-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• SMALL MOLECULE INHIBITOR OF THE NUCLEAR TRANSLOCATION OF ANDROGEN RECEPTOR FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER
  申请人：University of Pittsburgh- Of the Commonwealth System of Higher Education

  公开号：EP3433239A1

  公开（公告）日：2019-01-30
• [EN] SMALL MOLECULE INHIBITOR OF THE NUCLEAR TRANSLOCATION OF ANDROGEN RECEPTOR FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER<br/>[FR] INHIBITEUR DE TYPE PETITE MOLÉCULE DE LA TRANSLOCATION NUCLÉAIRE DU RÉCEPTEUR AUX ANDROGÈNES POUR LE TRAITEMENT DU CANCER DE LA PROSTATE RÉSISTANT À LA CASTRATION
  申请人：UNIV OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：WO2017165822A1

  公开（公告）日：2017-09-28

  A compound, or a stereoisomer, pharmaceutically acceptable salt, or ester thereof, according to formula (III) or according to Table A, a pharmaceutical composition comprising said compound and at least one pharmaceutically acceptable additive, and a method for treating prostate cancer in a subject, comprising administering to the subject a therapeutically effective amount of said compound.