二甲基甲氧基-N-丙基硅烷 | 18182-14-4

• 物质功能分类: 化学试剂 - 硅烷试剂
• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: 二甲基甲氧基-N-丙基硅烷
• 中文别名: 正丙基二甲基甲氧基硅烷；二甲基甲氧基-n-丙基硅烷
• 英文名称: methoxydimethyl(n-propyl)silane
• 英文别名: Propyldimethylmethoxysilan；methoxydimethylpropylsilane；Methoxy-dimethyl-propylsilane
• CAS: 18182-14-4
• 化学式: C₆H₁₆OSi
• mdl: MFCD01861725
• 分子量: 132.278
• InChiKey: NCHMPORHGFKNSI-UHFFFAOYSA-N

物化性质

• 沸点：
  111 °C
• 密度：
  0.787
• 闪点：
  -30 °C
• 稳定性/保质期：
  <p>遵照规定使用和储存，则不会分解。</p>

计算性质

• 辛醇/水分配系数(LogP)：
  2.35
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• TSCA：
  No
• 危险品标志：
  Xi-F,F,Xi
• 危险类别码：
  R36/37/38
• 海关编码：
  2931900090
• 安全说明：
  S16,S26,S37/39

SDS

Name:	Dimethylmethoxy-n-propylsilane Material Safety Data Sheet
Synonym:	Methoxy-n-propyldimethylsilan
CAS:	18182-14-4

Section 1 - Chemical Product MSDS Name:Dimethylmethoxy-n-propylsilane Material Safety Data Sheet
Synonym:Methoxy-n-propyldimethylsilan

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
18182-14-4	Dimethylmethoxy-n-propylsilane		unlisted

Hazard Symbols: XI F
Risk Phrases: 11 36/37/38

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause conjunctivitis. May cause blindness. Contact with the eyes may cause corneal damage.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May cause headache, nausea, fatigue, and dizziness. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Flammable liquid and vapor.
Extinguishing Media:
Use carbon dioxide or dry chemical.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Use a spark-proof tool.

---

Section 7 - HANDLING and STORAGE
Handling:
Use spark-proof tools and explosion proof equipment. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood.
Storage:
Keep away from sources of ignition. Store in a cool, dry place.
Store in a tightly closed container. Flammables-area.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 18182-14-4: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Clear liquid
Color: colorless
Odor: alcohol-like
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 111 deg C @760 mmHg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: -30 deg C ( -22.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Reacts.
Specific Gravity/Density:
Molecular Formula: CH3(CH2)2Si(CH3)2OCH3
Molecular Weight: 132.1969

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable.
Conditions to Avoid:
Ignition sources.
Incompatibilities with Other Materials:
Not available.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, silicon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 18182-14-4 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Dimethylmethoxy-n-propylsilane - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI F
Risk Phrases:
R 11 Highly flammable.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 18182-14-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 18182-14-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 18182-14-4 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  二甲基甲氧基-N-丙基硅烷 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 生成 甲醇 、 dimethyl-propyl-silanol
  参考文献：
  名称：

  Zur Reaktion von Silanolen mit Alkoholen

  摘要：

  DOI：

  10.1002/prac.199633801125
• 作为产物：
  描述：

  二甲基二甲氧基硅烷 、 丙基溴化镁 以 乙醚 为溶剂， 反应 19.0h， 以85%的产率得到二甲基甲氧基-N-丙基硅烷
  参考文献：
  名称：

  硅α效应：C的水解的系统的实验和计算研究α -和C γ -官能化Alkoxytriorganylsilanes式类型ROSiMe 2（CH 2）Ñ X（R =甲基，乙基; Ñ = 1,3; X =功能组）

  摘要：

  为了理解在式类型ROSiMe的α-硅烷中的Si-OC键的增强的反应性方面的硅α-效果2 CH 2 X相比类似的γ-硅烷ROSiMe 2（CH 2）3 X（R =我等; X =官能团），一个系统的实验和动力学和这样的化合物的水解的机制的计算研究进行。为了这个目的，一系列合适的模型化合物的合成和在CD研究了它们的水解动力学3 CN / d 2 o在碱性和酸性条件下，使用1H NMR光谱作为分析工具。为了获得有关反应机理的更多信息，实验研究得到了计算研究的补充。这些研究表明，硅α效应不能通过特殊的单一效应来合理化。观察到的反应性实际上是由不同成分的总和产生的，例如电子和空间效应，pD依赖性以及官能团（甚至是质子化的官能团）与烷氧基离去基团之间的氢键。因此，不应再使用术语“硅α-效应”来解释在有机基的α-或γ-位带有官能团的烷氧基有机基硅烷在硅原子上的水解反应性（所谓的α-或γ-硅烷）。

  DOI：

  10.1021/om500073m

文献信息

• Silicenium ions: A gas-phase radiolytic approach.
  作者：Giancarlo Angelini、Yeghis Keheyan、Giuseppe Laguzzi、Gaetano Lilla

  DOI：10.1016/s0040-4039(00)80444-x

  日期：1988.1

  The gas-phase protonation of vinyltrimethylsilane was carried out, using γ -radiolysis of methane. The ionic species, involved in the process, were trapped by nucleophilic attack of methanol.

  乙烯基三甲基硅烷的气相质子化是利用甲烷的γ射线辐解进行的。参与该过程的离子物种被甲醇的亲核攻击所俘获。
• AUNER, N.;GROBE, J., Z. ANORG. UND ALLG. CHEM., 1983, 500, N 5, 132-160
  作者：AUNER, N.、GROBE, J.

  DOI：——

  日期：——
• BOPOHKOB, M. G.;VVEDESKIJ, V. YU., ZH. OBSHCH. XIMII, 1985, 55, N 5, 1047-1051
  作者：BOPOHKOB, M. G.、VVEDESKIJ, V. YU.

  DOI：——

  日期：——
• Silicon α-Effect: A Systematic Experimental and Computational Study of the Hydrolysis of C_α- and C_γ-Functionalized Alkoxytriorganylsilanes of the Formula Type ROSiMe₂(CH₂)_<i>n</i>X (R = Me, Et; <i>n</i> = 1, 3; X = Functional Group)
  作者：André Berkefeld、Célia Fonseca Guerra、Rüdiger Bertermann、Dennis Troegel、Jürgen O. Daiß、Jürgen Stohrer、F. Matthias Bickelhaupt、Reinhold Tacke

  DOI：10.1021/om500073m

  日期：2014.6.9

  demonstrated that the silicon α-effect cannot be rationalized in terms of a special single effect. The reactivities observed rather result from a summation of different components, such as electronic and steric effects, pD dependence, and hydrogen bonds between the functional group (or even protonated functional group) and the alkoxy leaving group. Therefore, the term “silicon α-effect” should not be used furthermore

  为了理解在式类型ROSiMe的α-硅烷中的Si-OC键的增强的反应性方面的硅α-效果2 CH 2 X相比类似的γ-硅烷ROSiMe 2（CH 2）3 X（R =我等; X =官能团），一个系统的实验和动力学和这样的化合物的水解的机制的计算研究进行。为了这个目的，一系列合适的模型化合物的合成和在CD研究了它们的水解动力学3 CN / d 2 o在碱性和酸性条件下，使用1H NMR光谱作为分析工具。为了获得有关反应机理的更多信息，实验研究得到了计算研究的补充。这些研究表明，硅α效应不能通过特殊的单一效应来合理化。观察到的反应性实际上是由不同成分的总和产生的，例如电子和空间效应，pD依赖性以及官能团（甚至是质子化的官能团）与烷氧基离去基团之间的氢键。因此，不应再使用术语“硅α-效应”来解释在有机基的α-或γ-位带有官能团的烷氧基有机基硅烷在硅原子上的水解反应性（所谓的α-或γ-硅烷）。
• Zur Reaktion von Silanolen mit Alkoholen
  作者：I. Kohlheim、D. Lange、H. Kelling

  DOI：10.1002/prac.199633801125

  日期：——