(+/-)-4-[(3-fluorophenoxy)phenyl]Methyl-piperidine, Sulfate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (+/-)-4-[(3-fluorophenoxy)phenyl]Methyl-piperidine, Sulfate
• 英文别名: 4-[[2-(3-Fluorophenoxy)phenyl]methyl]piperidine;sulfuric acid
• 化学式: C₁₈H₂₀FNO*H₂O₄S
• 分子量: 383.441
• InChiKey: KUPVYIHWUYNIBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.51
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (+/-)-4-(phenylhydroxy)methyl-1-piperidinecarboxylic acid, 1,1-dimethyl-ethylester 、 aqueous NaCl 、 CHOAr carbon 、 1,3-二氟苯 、 Potassium benzoate 生成 (+/-)-4-[(3-fluorophenoxy)phenyl]Methyl-piperidine, Sulfate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulfonate: uses, process of synthesis and pharmaceutical compositions
  申请人：FAES FARMA, S.A.

  公开号：EP1854785A1

  公开（公告）日：2007-11-14

  The present patent application is directed to 4-[(3-fluorophenoxy)phenylmethyl] piperidine methanesulfonic acid salt (formula I), its synthesis and use in the manufacture of a medicament for the treatment and/or prevention of a serotonine and/or norepinephrine mediated disease or condition. The present invention is also directed to pharmaceutical compositions comprising the same.

  本专利申请涉及4-[(3-氟苯氧基)苯甲基]哌啶甲磺酸盐（化学式I），其合成以及在制造用于治疗和/或预防由血清素和/或去甲肾上腺素介导的疾病或病况的药物中的应用。本发明还涉及包含相同成分的药物组合物。
• 4-[(3-FLUOROPHENOXY)PHENYLMETHYL]PIPERIDINE METHANESULFONATE: USES, PROCESS OF SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS
  申请人：Orjales Venero Aurelio

  公开号：US20100004283A1

  公开（公告）日：2010-01-07

  The present patent application is directed to 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulfonic acid salt (formula I), its synthesis and use in the manufacture of a medicament for the treatment and/or prevention of a serotonine and/or norepinephrine mediated disease or condition. The present invention is also directed to pharmaceutical compositions comprising the same.

  本专利申请涉及4-[(3-氟苯氧基)苯基甲基]哌啶甲磺酸盐（式I），其合成和用于制造用于治疗和/或预防血清素和/或去甲肾上腺素介导的疾病或病况的药物。本发明还涉及包含相同化合物的制药组合物。
• [EN] 4-[(3-FLUOROPHENOXY)PHENYLMETHYL]PIPERIDINE METHANESULFONATE: USES, PROCESS OF SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS<br/>[FR] MÉTHANESULFONATE DE 4-[(3-FLUOROPHÉNOXY)PHÉNYLMÉTHYL]PIPÉRIDINE : UTILISATIONS, PROCÉDÉ DE SYNTHÈSE ET COMPOSITIONS PHARMACEUTIQUES
  申请人：FAES FARMA SA

  公开号：WO2007131846A1

  公开（公告）日：2007-11-22

  [EN] The present patent application is directed to 4-[(3-fluorophenoxy)phenylmethyl] piperidine methanesulfonic acid salt (formula I), its synthesis and use in the manufacture of a medicament for the treatment and/or prevention of a serotonine and/or norepinephrine mediated disease or condition. The present invention is also directed to pharmaceutical compositions comprising the same.
  [FR] La présente demande concerne le sel d'acide 4-[(3-fluorophénoxy)phénylméthyl]pipéridine méthanesulfonique (formule I), sa synthèse et son utilisation dans la fabrication d'un médicament pour traiter et/ou pour prévenir une maladie ou une condition à médiation par la sérotonine et/ou norépinéphrine. La présente invention concerne également des compositions pharmaceutiques comprenant ledit sel.