4-methoxy-1-((2'-hydroxy-1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-methoxy-1-((2'-hydroxy-1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine
• 英文别名: 2-(4-Methoxy-2,2,6,6-tetramethylpiperidin-1-yl)oxy-2-phenylethanol
• 化学式: C₁₈H₂₉NO₃
• 分子量: 307.433
• InChiKey: LRSBCTHESXLFDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-methoxy-1-((2'-hydroxy-1'-phenylethyl)oxy)-2,2,6,6-tetramethylpiperidine 在 三乙胺 、 三氯氧磷 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以33%的产率得到Phosphoric acid mono-[2-(4-methoxy-2,2,6,6-tetramethyl-piperidin-1-yloxy)-2-phenyl-ethyl] ester
  参考文献：
  名称：

  Polystyrene- and Poly(3-vinylpyridine)-Grafted Magnetite Nanoparticles Prepared through Surface-Initiated Nitroxide-Mediated Radical Polymerization

  摘要：

  Polymer-grafted magnetite (Fe3O4) nanoparticles (diameter about 10 nm) were prepared through a direct polymer grafting reaction from their surfaces. The chemisorbed initiator (TEMPO-based alkoxyamine) for nitroxide-mediated radical polymerization with a phosphoric acid group gave controlled polystyrene (PS) and poly(3-vinylpyridine) (P3VP) graft layers on the surface. The graft densities of polymers on the surfaces of magnetite particles were estimated at 0.12-0.20 chains/nm(2) by thermogravimetric analysis (TGA). The improvement in the dispersibility of PS-modified magnetite in good solvents was verified by ultraviolet-visible (UV-vis) absorption spectroscopy, transmission electron microscopy (TEM), and dynamic light scattering (DLS). In the case of P3VP-modified magnetite, the particles were stably dispersed in good solvents, by protonation, in acid solution, and by quarternization with iodomethane, in neutral aqueous solution. The magnetic response of the polymer-grafted magnetite against an external magnetic field was confirmed in the stable dispersion.

  DOI：

  10.1021/ma035523g

文献信息

• METHOD FOR PRODUCING POLYMER NANOCOMPOSITE, AND FLAME-RETARDANT POLYMER NANOCOMPOSITE FORMED BY THE PRODUCTION METHOD
  申请人：Kyushu University, National University Corporation

  公开号：EP2354166A1

  公开（公告）日：2011-08-10

  Disclosed is a method for producing a polymer nanocomposite, including: after expanding an interlayer space of a layered inorganic compound using an organic onium salt, immobilizing a radical polymerization initiator having a group represented by general formula (1) shown below on an interlayer surface of the layered inorganic compound via a covalent bond; and carrying out surface-initiated radical polymerization in a monomer from the immobilized radical polymerization initiator. Preferably, in the radical polymerization initiator having the group represented by the general formula (1), at least one of X1 to X3 in the formula is a chlorine atom, or R1 in the formula is a C1-25 alkylene group or a C2-25 alkenylene group optionally interrupted by an oxygen atom or an ester group and optionally substituted by a phenyl group: wherein, R1 represents a C1-25 alkylene group, a C2-25 alkenylene group, a C5-8 cycloalkylene group, or a C6-12 arylene group, each of which being optionally substituted by a C1-18 alkyl group, a phenyl group, or a cyano group and being optionally interrupted by an oxygen atom, a carbonyl group, an ester group, a phenylene group, an amide group, or an imino group, the substitution and the interruption being optionally combined with each other; and X1 to X3 each independently represent a halogen atom, a hydroxy group, a methyl group, an ethyl group, a methyloxy group, or an ethyloxy group.

  公开了一种生产聚合物纳米复合材料的方法，包括：在使用有机鎓盐扩大层状无机化合物的层间空间后，通过共价键将具有下图所示通式(1)所代表基团的自由基聚合引发剂固定在层状无机化合物的层间表面上；以及以固定的自由基聚合引发剂为单体进行表面引发的自由基聚合。优选地，在具有通式(1)所代表基团的自由基聚合引发剂中，式中X1至X3中至少有一个是氯原子，或者式中R1是C1-25亚烷基或C2-25烯基，可选择被氧原子或酯基打断，并可选择被苯基取代： 其中，R1代表C1-25亚烷基、C2-25烯基、C5-8环亚烷基或C6-12芳烯基，它们各自可选择被C1-18烷基、苯基或氰基取代，并可选择被氧原子、羰基、酯基、亚苯基、酰胺基或亚胺基打断，取代和打断可选择相互结合；X1 至 X3 各自独立地代表卤原子、羟基、甲基、乙基、甲氧基或乙氧基。
• Programmed Thermodynamic Formation and Structure Analysis of Star-like Nanogels with Core Cross-linked by Thermally Exchangeable Dynamic Covalent Bonds
  作者：Yoshifumi Amamoto、Yuji Higaki、Yasuhiro Matsuda、Hideyuki Otsuka、Atsushi Takahara

  DOI：10.1021/ja075447n

  日期：2007.10.1

  Programmed thermodynamic formation of star-like nanogels from designed diblock copolymers with thermally exchangeable dynamic covalent bonds in their side chains and structure analysis of the nanogels were performed. Linear diblock copolymers that consist of poly(methyl methacrylate) block and random copolymer block of methyl methacrylate (MMA) and methacrylic esters with alkoxyamine moiety were prepared by atom transfer radical polymerization (ATRP). By heating the diblock copolymers in anisole, a cross-linking reaction occurred as a result of the radical crossover reaction of alkoxyamine moieties to afford star-like nanogels. Kinetic studies have revealed that the cross-linking behavior reaches equilibrium at a given reaction time, with characteristic reaction behaviors for thermodynamic reactions being observed. The equilibrium structures of the star-like nanogels were controlled by the initial concentrations of diblock copolymers as well as their compositions and molecular weights. Furthermore, by heating the star-like nanogels with excess alkoxyamine, linear polymers were successfully regenerated. The molecular weights and sizes of the nanogels were evaluated by gel permeation chromatography-multiangle laser light scattering (GPC-MALLS) and small-angle X-ray scattering (SAXS) measurements, respectively, and the morphologies of the nanogels were directly observed by scanning force microscopy (SFM).
• Reversible cross-linking reactions of alkoxyamine-appended polymers under bulk conditions for transition between flow and rubber-like states
  作者：Jing Su、Yoshifumi Amamoto、Tomoya Sato、Masashi Kume、Taro Inada、Tomoyuki Ohishi、Yuji Higaki、Atsushi Takahara、Hideyuki Otsuka

  DOI：10.1016/j.polymer.2014.01.055

  日期：2014.3

  Reversible cross-linking reactions of alkoxyamine-appended polymers with low glass transition temperature (T-g) were successfully carried out under bulk conditions. The low-T-g polymers with alkoxyamine units in the side chains were synthesised by radical copolymerisation of 2-ethylhexyl acrylate and two kinds of alkoxyamine-containing acrylate monomers. By heating the low-Tg polymers under bulk conditions at 100 C, cross-linked polymers were formed by radical exchange reactions between alkoxyamine units, and a transition from a liquid-like flowable polymer state to a rubber-like polymer state was confirmed. A de-cross-linking reaction was also accomplished by radical exchange reactions between the cross-linked polymers and an added alkoxyamine-containing small molecule or stable nitroxyl radical, which resulted in transition to the flowable state again. The structural transition between low-Tg linear polymers and cross-linked polymers were characterised by H-1 and C-13 NMR spectroscopy, Fourier transform infrared spectroscopy, rheology measurement, swelling experiment, and gel permeation chromatography measurement. (c) 2014 Elsevier Ltd. All rights reserved.
• US8742044B2
  申请人：——

  公开号：US8742044B2

  公开（公告）日：2014-06-03
• Polystyrene- and Poly(3-vinylpyridine)-Grafted Magnetite Nanoparticles Prepared through Surface-Initiated Nitroxide-Mediated Radical Polymerization
  作者：Ryosuke Matsuno、Kazuya Yamamoto、Hideyuki Otsuka、Atsushi Takahara

  DOI：10.1021/ma035523g

  日期：2004.3.1

  Polymer-grafted magnetite (Fe3O4) nanoparticles (diameter about 10 nm) were prepared through a direct polymer grafting reaction from their surfaces. The chemisorbed initiator (TEMPO-based alkoxyamine) for nitroxide-mediated radical polymerization with a phosphoric acid group gave controlled polystyrene (PS) and poly(3-vinylpyridine) (P3VP) graft layers on the surface. The graft densities of polymers on the surfaces of magnetite particles were estimated at 0.12-0.20 chains/nm(2) by thermogravimetric analysis (TGA). The improvement in the dispersibility of PS-modified magnetite in good solvents was verified by ultraviolet-visible (UV-vis) absorption spectroscopy, transmission electron microscopy (TEM), and dynamic light scattering (DLS). In the case of P3VP-modified magnetite, the particles were stably dispersed in good solvents, by protonation, in acid solution, and by quarternization with iodomethane, in neutral aqueous solution. The magnetic response of the polymer-grafted magnetite against an external magnetic field was confirmed in the stable dispersion.