4-(dimethylphenylsiloxy)butanal

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 4-(dimethylphenylsiloxy)butanal
• 英文别名: 4-[Dimethyl(phenyl)silyl]oxybutanal
• 化学式: C₁₂H₁₈O₂Si
• 分子量: 222.359
• InChiKey: MZIVOHJTAOHCPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.09
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三甲氧基酯 、 一氧化碳 、 二甲基苯基硅烷 在 1-甲基吡唑 、 di(rhodium)tetracarbonyl dichloride 作用下， 以 甲苯 为溶剂， 50.0 ℃ 、5.07 MPa 条件下， 反应 12.0h， 以83%的产率得到4-(dimethylphenylsiloxy)butanal
  参考文献：
  名称：

  Ring-opening silylformylation of oxetanes catalyzed by [RhCl(CO)2]2-amine

  摘要：

  With [RhCl(CO)(2)](2)-amine as catalyst, the reaction of oxetanes with a hydrosilane and carbon monoxide results in ring-opening silylformylation to give gamma-siloxy aldehydes in 42-83% yields. Addition of amines is essential for the silylformylation to proceed, and 1-methylpyrazole is the most effective additive among the amines examined. The ring-opening of 2-alkyloxetanes occurs predominantly at the primary carbon atom with regioselectivity of 95%.

  DOI：

  10.1016/0022-328x(94)05274-f

文献信息

• Ring-opening silylformylation of oxetanes catalyzed by [RhCl(CO)2]2-amine
  作者：Yoshiya Fukumoto、Shinshi Yamaguchi、Naoto Chatani、Shinji Murai

  DOI：10.1016/0022-328x(94)05274-f

  日期：1995.3

  With [RhCl(CO)(2)](2)-amine as catalyst, the reaction of oxetanes with a hydrosilane and carbon monoxide results in ring-opening silylformylation to give gamma-siloxy aldehydes in 42-83% yields. Addition of amines is essential for the silylformylation to proceed, and 1-methylpyrazole is the most effective additive among the amines examined. The ring-opening of 2-alkyloxetanes occurs predominantly at the primary carbon atom with regioselectivity of 95%.