4-acetyl-1-methylpiperazine hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-acetyl-1-methylpiperazine hydrochloride
• 英文别名: 1-Acetyl-4-methylpiperazine hydrochloride；1-(4-methylpiperazin-1-yl)ethanone;hydrochloride
• 化学式: C₇H₁₄N₂O*ClH
• 分子量: 178.662
• InChiKey: MQTVMZTUPOGGGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  23.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲醇 、 1-乙酰哌嗪 在 Ag/TiO₂ 、 盐酸 作用下， 以 乙醚 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 反应 22.0h， 以97%的产率得到4-acetyl-1-methylpiperazine hydrochloride
  参考文献：
  名称：

  N-Methylation of Amines with Methanol at Room Temperature

  摘要：

  N-Methylation of amines with methanol proceeds at room temperature in the presence of a silver-loaded titanium dioxide (Ag/TiO2) photocatalyst under UV-vis light irradiation. This method allows facile synthesis/isolation of N-methylamines bearing various functional groups including N-benzyl, N-allyl, N-Boc, hydroxyl, ether, acetal, carboxamide, formamide, and olefin groups.

  DOI：

  10.1021/acs.orglett.5b01063

文献信息

• [EN] COMPOSITIONS AND METHODS FOR INDUCING OR SUPPLEMENTING SOCS3 TO ABROGATE TUMOR GROWTH AND PROLIFERATIVE RETINOPATHY<br/>[FR] COMPOSITIONS ET MÉTHODES POUR INDUIRE OU RENFORCER UN SOCS3 AFIN DE BLOQUER LA CROISSANCE TUMORALE ET LA RÉTINOPATHIE PROLIFÉRANTE
  申请人：CHILDRENS MEDICAL CENTER

  公开号：WO2020150584A1

  公开（公告）日：2020-07-23

  The invention provides compositions and methods for inhibiting tumor growth by up- regulating and/or supplementing SOCS3 in tumor and/or tumor-associated tissues of a subject or in cells in vitro. Compounds capable of up-regulating SOCS3, including flavanones, or otherwise of up-regulating the ACh pathway, e.g., at the NMJ, are identified and provided, as are methods for identifying additional agents as inducers of SOCS3.