2-[[4-(2-methylphenyl)piperazin-1-yl]methyl]-3H-quinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[[4-(2-methylphenyl)piperazin-1-yl]methyl]-3H-quinazolin-4-one
• 化学式: C₂₀H₂₂N₄O
• 分子量: 334.4
• InChiKey: CBPKXCZQEUAGAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• METHODS FOR THE PREPARATION OF HYDROXY-SUBSTITUTED ARYL SULFAMIDE COMPOUNDS
  申请人：Papamichelakis Maria

  公开号：US20090156826A1

  公开（公告）日：2009-06-18

  The present invention is directed to processes for the preparation of hydroxy-substituted aryl sulfamide derivatives of the formula I or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, which are monoamine reuptake inhibitors wherein the constituent variables are as defined herein.

  本发明涉及制备式I的羟基取代芳基磺酰胺衍生物或其药学上可接受的盐、立体异构体或互变异构体的过程，其中所述衍生物是单胺再摄取抑制剂，其组成变量如本文所定义。
• [EN] METHODS FOR THE PREPARATION OF HYDROXY-SUBSTITUTED ARYL SULFAMIDE COMPOUNDS<br/>[FR] PROCÉDÉS DE PRÉPARATION DE COMPOSÉS ARYL SULFAMIDE SUBSTITUÉS PAR HYDROXY
  申请人：WYETH CORP

  公开号：WO2009076502A1

  公开（公告）日：2009-06-18

  The present invention is directed to processes for the preparation of hydroxy-substituted aryl sulfamide derivatives of the formula I or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, which are monoamine reuptake inhibitors wherein the constituent variables are as defined herein, formula ( I ).

  本发明涉及制备式I的羟基取代的芳基磺酰胺衍生物或其药学上可接受的盐、立体异构体或互变异构体的过程，其为单胺再摄取抑制剂，其中组分变量如本文所定义的公式(I)。
• ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE
  申请人：McComas Casey Cameron

  公开号：US20100029641A1

  公开（公告）日：2010-02-04

  The present invention is directed to aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

  本发明涉及公式I的芳基磺酰胺衍生物： 或其药学上可接受的盐、立体异构体或互变异构体，它们是单胺再摄取抑制剂，包含这些衍生物的组合物以及它们的使用方法，用于预防和治疗多种疾病或疾病，包括但不限于血管运动症状、性功能障碍、胃肠障碍和泌尿生殖障碍、抑郁症、内源性行为障碍、认知障碍、糖尿病神经病变、疼痛和其他疾病或障碍。
• Heterocyclic Compounds And Uses Thereof In The Treatment Of Sexual Disorders
  申请人：Tworowski Dmitry

  公开号：US20100029671A1

  公开（公告）日：2010-02-04

  Novel heterocyclic compounds, which exhibit a dopamine receptor (preferably a D4 receptor) agonistic activity, and/or a PDE5 inhibitory activity, processes of preparing same, pharmaceutical compositions containing same and uses thereof in the treatment of sexual disorders such as decreased libido, orgasm disorder and erectile dysfunction are disclosed.

  本发明揭示了一种新型杂环化合物，其表现出多巴胺受体（优选为D4受体）激动活性和/或PDE5抑制活性，以及制备该化合物的方法，含有该化合物的药物组合物以及将其用于治疗性功能障碍，如性欲减退、性高潮障碍和勃起功能障碍的用途。
• AMINOALKYL SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE
  申请人：McComas Casey Cameron

  公开号：US20080161366A1

  公开（公告）日：2008-07-03

  The present invention is directed to aminoalkyl-substituted aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

  本发明涉及公式I的氨基烷基取代芳基磺酰胺衍生物，或其药学上可接受的盐、立体异构体或互变异构体，它们是单胺再摄取抑制剂，包含这些衍生物的组合物，以及它们用于预防和治疗症状，包括但不限于血管运动症状、性功能障碍、胃肠障碍和泌尿生殖障碍、抑郁症、内源性行为障碍、认知障碍、糖尿病神经病变、疼痛和其他疾病或障碍的方法。