1,3,5-tris-(3-diallylamino-2-hydroxy-propyl)-[1,3,5]triazine-2,4,6-trione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 1,3,5-tris-(3-diallylamino-2-hydroxy-propyl)-[1,3,5]triazine-2,4,6-trione
• 英文别名: 1,3,5-Tris[3-[bis(prop-2-enyl)amino]-2-hydroxypropyl]-1,3,5-triazinane-2,4,6-trione
• 化学式: C₃₀H₄₈N₆O₆
• 分子量: 588.748
• InChiKey: ZZFFWXPYIRLAJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  42
• 可旋转键数：
  24
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  1,3,5-tris-(3-diallylamino-2-hydroxy-propyl)-[1,3,5]triazine-2,4,6-trione 、 dithiothreitol 在 偶氮二异丁腈 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 48.0h， 生成 Methyl 1-[2-[3-[2-[3-[[3-[3,5-bis[3-[3-[2-[bis[3-[2-(4-methoxycarbonyl-2-oxopyrrolidin-1-yl)ethylamino]-3-oxopropyl]amino]ethylsulfanyl]propyl-prop-2-enylamino]-2-hydroxypropyl]-2,4,6-trioxo-1,3,5-triazinan-1-yl]-2-hydroxypropyl]-prop-2-enylamino]propylsulfanyl]ethyl-[3-[2-(4-methoxycarbonyl-2-oxopyrrolidin-1-yl)ethylamino]-3-oxopropyl]amino]propanoylamino]ethyl]-5-oxopyrrolidine-3-carboxylate
  参考文献：
  名称：

  WO2006/105043

  摘要：

  公开号：
• 作为产物：
  描述：

  1,3,5-三缩水甘油-S-三嗪三酮 、 二烯丙基胺 以 甲醇 为溶剂， 反应 24.0h， 以98.6%的产率得到1,3,5-tris-(3-diallylamino-2-hydroxy-propyl)-[1,3,5]triazine-2,4,6-trione
  参考文献：
  名称：

  [EN] DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY
  [FR] POLYMERES DENDRITIQUES AVEC FONCTIONNALITE INTERIEURE ET AMPLIFICATION RENFORCEES

  摘要：

  公开号：

  WO2006115547A3

文献信息

• Janus Dendrimers and Dendrons
  申请人：Tomalia Donald A.

  公开号：US20080221300A1

  公开（公告）日：2008-09-11

  This invention provides a cost effective process and new Janus dendrimers where at least two dendrons are attached at the core (with or without a connector group) and where at least two of the dendrons have different functionality. Preferred are those Janus dendrimers where at least one dendron is a PEHAM dendron. Thus these Janus dendrimers are heterobifunctional in character and use unique ligation chemistry with single site functional dendrons, di-dendrons and multi-dendrons. Also included are Janus dendrons which maybe used as intermediates to make the Janus dendrimers or to further react with another reactive moiety. These Janus dendrimers can provide several new dendrimer moieties, namely: combinatorial libraries of bifunctional structures; combined target director and signaling dendrimers; specific targeting entities for diagnostic and therapeutic applications, such as for example targeted MRI agents, targeted radionuclide delivery for diseases such as cancer, and targeted photosensitive or radiowave sensitive agents.

  该发明提供了一种经济有效的过程和新的Janus树状分子，其中至少有两个树枝附着在核心上（带有或不带有连接器组），并且至少有两个树枝具有不同的功能。首选的是至少一个树枝是PEHAM树枝的Janus树状分子。因此，这些Janus树状分子具有异双功能性质，并且使用具有单个位点功能树枝，二元树枝和多元树枝的独特连接化学。还包括可以用作制备Janus树状分子的中间体或进一步与另一反应性基团反应的Janus树枝。这些Janus树状分子可以提供几种新的树状分子基团，即：双功能结构的组合库；结合目标指向和信号传导的树状分子；用于诊断和治疗应用的特定靶向实体，例如用于靶向MRI剂、针对癌症等疾病的靶向放射性核素传递和靶向光敏或辐射波敏感剂。
• JANUS DENDRIMERS AND DENDRONS
  申请人：Dendritic Nanotechnologies, Inc.

  公开号：EP1869106A2

  公开（公告）日：2007-12-26
• Dendritic Polymers With Enhanced Amplification and Interior Functionality
  申请人：Tomalia A. Donald

  公开号：US20070298006A1

  公开（公告）日：2007-12-27

  Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.
• US7977452B2
  申请人：——

  公开号：US7977452B2

  公开（公告）日：2011-07-12
• US7985424B2
  申请人：——

  公开号：US7985424B2

  公开（公告）日：2011-07-26