人体β-1,4-半乳糖转移酶I重组体来源于酿酒酵母 | 37237-43-7

• 分子结构分类: 转移酶 - 糖基转移酶 - 己糖基转移酶
• 中文名称: 人体β-1,4-半乳糖转移酶I重组体来源于酿酒酵母
• 中文别名: 人体Β-1,4-半乳糖转移酶I重组体来源于酿酒酵母；人体&Beta-1,4-半乳糖转移酶I重组体来源于酿酒酵母
• 英文名称: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
• 英文别名: UDP-galactose---glycoprotein galactosyltransferase；glycoprotein 4-beta-galactosyl-transferase；beta-N-acetyl-beta1-4-galactosyltransferase；thyroid glycoprotein beta-galactosyltransferase；glycoprotein beta-galactosyltransferase；thyroid galactosyltransferase；uridine diphosphogalactose-glycoprotein galactosyltransferase；beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase；GalT；UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase；UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase；β(1-4)galactosyl-transferase
• CAS: 37237-43-7；9054-94-8

反应信息

• 作为试剂：
  描述：

  1-deoxy-1-azido-β-D-glucohexopranosiduronic acid 在 人体β-1,4-半乳糖转移酶I重组体来源于酿酒酵母 苯磺酰胺 、 sodium methylate 、 O-Benzotriazol-1-yl-N,N,N',N'-bis(tetramethylene)uronium hexafluorophosphate 、 三乙胺 、 manganese(ll) chloride 作用下， 以 甲醇 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 148.0h， 生成 8-methoxycarbonyloctyl β-D-galactopyranosyl-(1-4)-2-deoxy-2-(1-deoxy-1-azido-β-D-glucohexopyranosyluronamide)-β-D-glucopyranoside
  参考文献：
  名称：

  Synthesis of linear-B saccharopeptides via enzymatic galactosylation of non-natural glucosamide acceptors

  摘要：

  A series of D- and L-glycopyranuronic acids are coupled to glucosamines to give saccharopeptides. These 'disaccharides'. in which the acetyl moiety of the natural N-acetyl-glucosamine is replaced by various sugar acids, turned out to be surprisingly good substrates for beta (1-4)-galactosyl-transferase and alpha (1-3)-galactosyl-transferase. The enzymes transfer successively two galactose units from the donor UDP-galactose onto these acceptor substrates. despite the far reaching, alterations, regio- and stereospecifically in the expected manner to give linear-B saccharopeptides. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00086-4