PCM-0102360

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: PCM-0102360
• 英文别名: N-[(1-adamantylamino)-oxomethyl]-2-chloroacetamide；N-(1-adamantylcarbamoyl)-2-chloroacetamide
• 化学式: C₁₃H₁₉ClN₂O₂
• mdl: MFCD03961692
• 分子量: 270.759
• InChiKey: OBLFEICGDWLKQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.846
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• IN VIVO ENGINEERED CEREBLON PROTEIN
  申请人：Vividion Therapeutics, Inc.

  公开号：US20200216507A1

  公开（公告）日：2020-07-09

  Disclosed herein are in vivo engineered cereblon protein and methods of making the same. The in vivo engineered cereblon protein can include a site-specific non-naturally occurring modification at cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO: 2 or 3, the modification comprising a moiety resulting from an in vivo Michael addition reaction between an exogenous Michael acceptor and the cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO: 2 or 3.