tert.Amyl-tert.butyl-monocarbonat

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: tert.Amyl-tert.butyl-monocarbonat
• 英文别名: Tert-butyl 2,2-dimethylpropyl carbonate
• 化学式: C₁₀H₂₀O₃
• 分子量: 188.267
• InChiKey: HHFHOYMHJRQYEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  新戊醇 、 二碳酸二叔丁酯 在 4-二甲氨基吡啶 作用下， 以 乙腈 为溶剂， 以60%的产率得到tert.Amyl-tert.butyl-monocarbonat
  参考文献：
  名称：

  Di-tert-butyl Dicarbonate and 4-(Dimethylamino)pyridine Revisited. Their Reactions with Amines and Alcohols¹

  摘要：

  The reaction of BOC2O in the presence and absence of DMAP was examined with some amines, alcohols, diols, amino alcohols, and aminothiols. Often, unusual products were observed depending on the ratio of reagents, reaction time, polarity of solvent, pK(a) of alcohols, or type of amine (primary or secondary). In reactions of aliphatic alcohols with BOC2O/DMAP, we isolated for the first time carbonic-carbonic anhydride intermediates; this helps explain the formation of symmetrical carbonates in addition to the O-BOC products. In the case of secondary amines, we succeeded to isolate unstable carbamic-carbonic anhydride intermediates that in the presence of DMAP led to the final N-BOC product. The effect of N-methylimidazole in place of DMAP was also examined.

  DOI：

  10.1021/jo000257f

文献信息

• Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same
  申请人：CHO Dong-Gyu

  公开号：US20100004440A1

  公开（公告）日：2010-01-07

  The present invention relates to an acyclic nucleoside phosphonate derivative which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.

  本发明涉及一种无环核苷酸膦酸酯衍生物，其可用作抗病毒剂（特别是针对乙型肝炎病毒），药学上可接受的盐，立体异构体以及其制备方法。
• Synthesis and kinetics of decomposition of di-tert-butyl tricarbonate, di-tert-butyl dithioltricarbonate, and the related dicarbonates
  作者：Christopher S. Dean、D. Stanley Tarbell、A. W. Friederang

  DOI：10.1021/jo00835a045

  日期：1970.10
• SUBSTITUTED CYCLIC PYRROLIDINE DERIVATIVES
  申请人：Qiu Yao-Ling

  公开号：US20090324544A1

  公开（公告）日：2009-12-31

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral (particularly HCV) infection in a subject in need of such therapy with said compounds.
• CARBACEPHEM BETA-LACTAM ANTIBIOTICS
  申请人：Wagman Allan S.

  公开号：US20100267686A1

  公开（公告）日：2010-10-21

  Carbacephem β-lactam antibiotics having the following chemical structures (I) and (II) are disclosed: including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar 2 , R 1 , R 2 and R 3 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
• US7157448B2
  申请人：——

  公开号：US7157448B2

  公开（公告）日：2007-01-02