2-(6,7-dimethyl-1-benzofuran-3-yl)-N-1,3-thiazol-2-ylacetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-(6,7-dimethyl-1-benzofuran-3-yl)-N-1,3-thiazol-2-ylacetamide
• 英文别名: 2-(6,7-dimethyl-1-benzofuran-3-yl)-N-(1,3-thiazol-2-yl)acetamide
• 化学式: C₁₅H₁₄N₂O₂S
• 分子量: 286.4
• InChiKey: YKUPLNSYIOVCLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  83.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS D'UBIQUITINE LIGASE CULLIN RING ET UTILISATIONS ASSOCIÉES
  申请人：[en]CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH

  公开号：WO2022079290A2

  公开（公告）日：2022-04-21

  The present invention relates to compounds with the ability to stimulate/induce ubiquitination of a target protein/target proteins. The compounds of the present invention may stimulate/induce ubiquitination of a target protein/target proteins; i.e. via degradation of a target protein/target proteins by the cullin-RING ubiquitin ligase (CRL). Such target protein/ target proteins may be proteins involved in diseases, like cancer, metabolic disorder, infectious disease and/or neurological disorder. The invention also relates to the compounds and composition for use as medicaments as well as pharmaceutical compositions comprising these compounds. Particularly, the compounds of the present invention may degrade proteins associated with cancer, metabolic disorder, infectious disease and/or neurological disorder. Furthermore, the present invention relates the compounds for use as a medicament, such as for use in treating cancer, metabolic disorder, infectious disease and/or neurological disorder and to a method for treating a disease, such as cancer, metabolic disorder, infectious disease and/or neurological disorder, comprising administering the compound of the present invention.