1-<<2,2-dimethyl-3-<(trimethylsilyl)oxy>propyl>oxy>-6-methylcyclohex-1-ene

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 1-<<2,2-dimethyl-3-<(trimethylsilyl)oxy>propyl>oxy>-6-methylcyclohex-1-ene
• 英文别名: [2,2-Dimethyl-3-(6-methylcyclohexen-1-yl)oxypropoxy]-trimethylsilane
• 化学式: C₁₅H₃₀O₂Si
• 分子量: 270.488
• InChiKey: JBSUBWCYLVVROA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.58
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲基环己酮 在 对甲苯磺酸 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 16.0h， 生成 1-<<2,2-dimethyl-3-<(trimethylsilyl)oxy>propyl>oxy>-6-methylcyclohex-1-ene
  参考文献：
  名称：

  Synthesis of cyclic and acyclic enol ethers (vinyl ethers)

  摘要：

  A general method has been developed for the conversion of both cyclic and acyclic acetals of cyclic ketones, acyclic ketones, and aldehydes into enol ethers through treatment of the acetal with trimethylsilyl triflate in the presence of N,N-diisopropylethylamine. The range of isolated yields of enol ethers from the various classes of acetals was as follows: cyclic acetals of cyclic ketones, 83-98%; acyclic acetals of ketones, 72-94%; acyclic and cyclic acetals of aldehydes, 65-90%.

  DOI：

  10.1021/jo00058a027

文献信息

• Synthesis of cyclic and acyclic enol ethers (vinyl ethers)
  作者：Paul G. Gassman、Stephen J. Burns、Keith B. Pfister

  DOI：10.1021/jo00058a027

  日期：1993.3

  A general method has been developed for the conversion of both cyclic and acyclic acetals of cyclic ketones, acyclic ketones, and aldehydes into enol ethers through treatment of the acetal with trimethylsilyl triflate in the presence of N,N-diisopropylethylamine. The range of isolated yields of enol ethers from the various classes of acetals was as follows: cyclic acetals of cyclic ketones, 83-98%; acyclic acetals of ketones, 72-94%; acyclic and cyclic acetals of aldehydes, 65-90%.