6-[4-(5-fluoro-2-trifluoromethylbenzoyl)piperazin-1-yl]imidazo[1,2-b]pyridazine-2-carboxylic acid (3-methylbutyl)amide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-[4-(5-fluoro-2-trifluoromethylbenzoyl)piperazin-1-yl]imidazo[1,2-b]pyridazine-2-carboxylic acid (3-methylbutyl)amide
• 英文别名: 6-[4-[5-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-N-(3-methylbutyl)imidazo[1,2-b]pyridazine-2-carboxamide
• 化学式: C₂₄H₂₆F₄N₆O₂
• 分子量: 506.503
• InChiKey: WFNHQQPAILHHHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  82.8
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  异戊胺 、 6-[4-(5-fluoro-2-trifluoromethylbenzoyl)piperazin-1-yl]imidazo[1,2-b]pyridazine-2-carboxylic acid ethyl ester 在 氰化钠 作用下， 以85%的产率得到6-[4-(5-fluoro-2-trifluoromethylbenzoyl)piperazin-1-yl]imidazo[1,2-b]pyridazine-2-carboxylic acid (3-methylbutyl)amide
  参考文献：
  名称：

  [EN] BICYCLIC HETEROCYCLIC DERIVATIVES AND THEIR USE AS INHIBITORS OF STEAROYL-COA-DESATURASE (SCD)
  [FR] DERIVES HETEROCYCLIQUES BICYCLIQUES ET LEUR UTILISATION COMME INHIBITEURS DE STEAROYL-COA DESATURASE (SCD)

  摘要：

  本发明涉及治疗哺乳动物，优选为人类，中SCD介导的疾病或病况的方法，其中该方法包括，例如，向需要的哺乳动物施用式(I)的化合物，其中x、y、J、K、L、M、W、V、R2、R3、R5、R5a、R6、R6a、R7、R7a、R8和R8a在此处定义。还披露了包含式(I)的化合物的药物组合物。

  公开号：

  WO2006034312A1

文献信息

• Bicyclic Heterocyclic Derivatives and Their Use as Inhibitors of Stearoyl-Coadesaturase (Scd)
  申请人：Kamboj Rajender

  公开号：US20070219211A1

  公开（公告）日：2007-09-20

  Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise, for example, administering to a mammal in need thereof a compound of formula (I): where x, y, J, K, L, M, W, V, R 2 , R 3 , R 5 , R 5a , R 6 , R 6a , R 7 , R 7a , R 8 and R 8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

  本发明揭示了治疗哺乳动物，特别是人类SCD介导的疾病或病况的方法，其中方法包括例如向需要的哺乳动物中给予公式（I）的化合物，其中x、y、J、K、L、M、W、V、R2、R3、R5、R5a、R6、R6a、R7、R7a、R8和R8a在此被定义。还揭示了包含公式（I）化合物的制药组合物。
• HETEROCYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
  申请人：Kamboj Rajender

  公开号：US20090291957A1

  公开（公告）日：2009-11-26

  Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise, for example, administering to a mammal in need thereof a compound of formula (II): where x, y, A, D, E, T, Q, G, Z, J, K, L, M, W, V, R 2 , R 3 , R 5 , R 5a , R 6 , R 6a , R 7 , R 7a , R 8 and R 8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (II) are also disclosed.

  本文揭示了治疗哺乳动物，尤其是人类SCD介导的疾病或病况的方法，其中方法包括例如向需要该方法的哺乳动物内给予式（II）的化合物，其中x，y，A，D，E，T，Q，G，Z，J，K，L，M，W，V，R2，R3，R5，R5a，R6，R6a，R7，R7a，R8和R8a在此被定义。还揭示了包含式（II）化合物的制药组合物。
• Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coadesaturase (SCD)
  申请人：Xenon Pharmaceuticals Inc.

  公开号：US07547698B2

  公开（公告）日：2009-06-16

  Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise, for example, administering to a mammal in need thereof a compound of formula (I): where x, y, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

  本发明揭示了治疗哺乳动物，尤其是人类SCD介导的疾病或病症的方法，其中所述方法包括例如向需要的哺乳动物给予公式（I）的化合物，其中x，y，J，K，L，M，W，V，R2，R3，R5，R5a，R6，R6a，R7，R7a，R8和R8a在此被定义。还揭示了包含公式（I）化合物的药物组合物。
• [EN] BICYCLIC HETEROCYCLIC DERIVATIVES AND THEIR USE AS INHIBITORS OF STEAROYL-COA-DESATURASE (SCD)<br/>[FR] DERIVES HETEROCYCLIQUES BICYCLIQUES ET LEUR UTILISATION COMME INHIBITEURS DE STEAROYL-COA DESATURASE (SCD)
  申请人：XENON PHARMACEUTICALS INC

  公开号：WO2006034312A1

  公开（公告）日：2006-03-30

  Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise, for example, administering to a mammal in need thereof a compound of formula (I): where x, y, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

  本发明涉及治疗哺乳动物，优选为人类，中SCD介导的疾病或病况的方法，其中该方法包括，例如，向需要的哺乳动物施用式(I)的化合物，其中x、y、J、K、L、M、W、V、R2、R3、R5、R5a、R6、R6a、R7、R7a、R8和R8a在此处定义。还披露了包含式(I)的化合物的药物组合物。