1-tert-butyl-3,3-dimethyl-2-ethylthio-5-methoxypiperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-tert-butyl-3,3-dimethyl-2-ethylthio-5-methoxypiperidine
• 英文别名: 1-Tert-butyl-2-ethylsulfanyl-5-methoxy-3,3-dimethylpiperidine
• 化学式: C₁₄H₂₉NOS
• 分子量: 259.456
• InChiKey: HRXGEIIXQSFKPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  37.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-tert-butyl-3,3-dimethyl-5-methoxy-1-piperideinium bromide 、 乙硫醇钠 反应 2.0h， 以86%的产率得到1-tert-butyl-3,3-dimethyl-2-ethylthio-5-methoxypiperidine
  参考文献：
  名称：

  Synthesis of 2,5-difunctionalised-3,3-dimethylpiperidines via ω-halogenated imines

  摘要：

  2,5-Difunctionalised-3,3-dimethylpiperidines were prepared by addition of nucleophiles to piperideinium salts, formed by electrophile-induced cyclisation of gamma,delta -unsaturated imines with N-bromosuccinimide in alcoholic medium. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00762-1

文献信息

• Synthesis of 2,5-difunctionalised-3,3-dimethylpiperidines via ω-halogenated imines
  作者：Christian V Stevens、Maria Peristeropoulou、Norbert De Kimpe

  DOI：10.1016/s0040-4020(01)00762-1

  日期：2001.9

  2,5-Difunctionalised-3,3-dimethylpiperidines were prepared by addition of nucleophiles to piperideinium salts, formed by electrophile-induced cyclisation of gamma,delta -unsaturated imines with N-bromosuccinimide in alcoholic medium. (C) 2001 Elsevier Science Ltd. All rights reserved.