2-N-methylamino-5-methylthiophene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 2-N-methylamino-5-methylthiophene
• 英文别名: Methyl(5-methyl-2-thienyl)amine；N,5-dimethylthiophen-2-amine
• 化学式: C₆H₉NS
• 分子量: 127.21
• InChiKey: ZTSQIICLBFATFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-丁炔 、 异硫氰酸甲酯 生成 2-N-methylamino-5-methylthiophene
  参考文献：
  名称：

  One-Pot Syntheses of 2-N-Alkylamino-, 2-N-Phenylamino-, 2-N, N-Dialkylamino-, and 2-N-Alkyl-N-phenylaminothiophenes

  摘要：

  DOI：

  10.1002/(sici)1099-0690(199802)1998:2<253::aid-ejoc253>3.0.co;2-e

文献信息

• [EN] ANTIPROLIFERATIVE 2-(SULFO-PHENYL)-AMINOTHIAZOLE DERIVATIVES<br/>[FR] DERIVES DE 2-(SULFO-PHENYL)-AMINOTHIAZOLE ANTIPROLIFERATIFS
  申请人：PFIZER

  公开号：WO2004072070A1

  公开（公告）日：2004-08-26

  Aminothiazole compounds substituted with sulfur-containing groups are represented by the Formula (I), and their pharmaceutically acceptable salts, prodrugs, active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

  含有硫基取代基团的氨基噻唑化合物由化学式(I)表示，并描述了它们的药用可接受盐、前药、活性代谢物以及所述代谢物的药用可接受盐。这些药物调节和/或抑制细胞增殖和蛋白激酶活性，可用作治疗恶性肿瘤和其他疾病的药物。
• [EN] SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS<br/>[FR] PYRAZOLO[4,3-B]PYRIDINES SUBSTITUÉES ET LEUR UTILISATION EN TANT QUE MODULATEURS DU RÉCEPTEUR GLUN2B
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2020249791A1

  公开（公告）日：2020-12-17

  Substituted pyrazolo[4,3-b]pyridines as GluN2B receptor ligands. Such compounds may be used in GluN2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by GluN2B receptor activity.

  取代的吡唑[4,3-b]吡啶作为GluN2B受体配体。这些化合物可用于GluN2B受体调节以及用于治疗由GluN2B受体活性介导的疾病状态、疾病和疾病的制药组合物和方法。
• PESTICIDAL PYRIMIDINE COMPOUNDS
  申请人：Dow AgroSciences LLC

  公开号：US20140134271A1

  公开（公告）日：2014-05-15

  Pyrimidine compounds and their use in controlling pests such as insects and other invertebrates are provided. Further embodiments, forms, objects, features, advantages, aspects and benefits shall become apparent from the description.

  提供了嘧啶化合物及其在控制害虫如昆虫和其他无脊椎动物方面的用途。进一步的实施形式、形态、对象、特征、优势、方面和好处将从描述中变得明显。
• Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives and pharmaceutical compositions, and methods for their use
  申请人：Pfizer, Inc.

  公开号：US20040176431A1

  公开（公告）日：2004-09-09

  Aminothiazole compounds substituted with sulfur-containing groups are represented by the Formula (I), and their pharmaceutically acceptable salts, prodrugs, active metabolites, and pharmaceutically acceptable salts of said metabolites are described. 1 These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

  含有硫基取代的氨基噻唑化合物的化学式为(I)，其药物可接受的盐、前药、活性代谢物和药物可接受的代谢物的描述如下。这些药物可以调节和/或抑制细胞增殖和蛋白激酶活性，是治疗恶性肿瘤和其他疾病的药物。
• [EN] 6-SUBSTITUTED 1-SULFONYL-2, 3-DIHYDRO-INDOLE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES<br/>[FR] DÉRIVÉS 1-SULFONYL-2,3-DIHYDRO-INDOLES SUBSTITUÉS EN POSITION 6 DESTINÉS AU TRAITEMENT DE MALADIES PROLIFÉRATIVES
  申请人：EUROPEAN MOLECULAR BIOLOGY LAB EMBL

  公开号：WO2010017827A1

  公开（公告）日：2010-02-18

  The present invention relates to indoline-sulfonamide compounds according to general structural formula (I), pharmaceutical compositions comprising a compound of the invention. Further provided is the use of a compound or a composition according to the invention for the preparation of a medicament for the treatment of a proliferative disease, in particular the treatment of cancer.

  本发明涉及通用结构式(I)的吲哚磺酰胺化合物，包括一种本发明化合物的制药组合物。本发明还提供了利用本发明化合物或组合物制备用于治疗增生性疾病的药物，特别是治疗癌症的用途。