2-(4-(2-fluorophenyl)piperazin-1-yl)benzo[d]oxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-(2-fluorophenyl)piperazin-1-yl)benzo[d]oxazole
• 英文别名: 2-[4-(2-Fluorophenyl)piperazin-1-yl]-1,3-benzoxazole
• 化学式: C₁₇H₁₆FN₃O
• 分子量: 297.332
• InChiKey: ITCLSLRFOQWPKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  32.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氯苯并恶唑 、 1-(2-氟苯基)哌嗪 以 水 为溶剂， 反应 2.0h， 以82%的产率得到2-(4-(2-fluorophenyl)piperazin-1-yl)benzo[d]oxazole
  参考文献：
  名称：

  Metal free amination of 2-chloroazoles in aqueous medium

  摘要：

  A green approach for the synthesis of 2-amino azoles by the reaction of 2-chloro azoles with various types of amines using water as an environment friendly solvent at room temperature has been developed. The significant features of this methodology are short reaction time and easy product separation. This approach provides various biologically active compounds in good to excellent yields without adding any catalyst, ligand, or base. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.12.084

文献信息

• Metal free amination of 2-chloroazoles in aqueous medium
  作者：R. Uday Kumar、K. Harsha Vardhan Reddy、B.S.P. Anil Kumar、G. Satish、V. Prakash Reddy、Y.V.D. Nageswar

  DOI：10.1016/j.tetlet.2015.12.084

  日期：2016.2

  A green approach for the synthesis of 2-amino azoles by the reaction of 2-chloro azoles with various types of amines using water as an environment friendly solvent at room temperature has been developed. The significant features of this methodology are short reaction time and easy product separation. This approach provides various biologically active compounds in good to excellent yields without adding any catalyst, ligand, or base. (C) 2015 Elsevier Ltd. All rights reserved.