3-(biphenyl-4-yl)quinuclidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(biphenyl-4-yl)quinuclidine
• 英文别名: 3-(4-Phenylphenyl)-1-azabicyclo[2.2.2]octane
• 化学式: C₁₉H₂₁N
• 分子量: 263.382
• InChiKey: ONKAPNPOBBUQAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Modulation of squalene synthase expression
  申请人：Isis Pharmaceuticals Inc.

  公开号：US20040102405A1

  公开（公告）日：2004-05-27

  Compounds, compositions and methods are provided for modulating the expression of squalene synthase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding squalene synthase. Methods of using these compounds for modulation of squalene synthase expression and for diagnosis and treatment of disease associated with expression of squalene synthase are provided.

  提供了调节角鲨烯合成酶表达的化合物、组合物和方法。这些组合物包括寡核苷酸，以编码角鲨烯合成酶的核酸为靶标。提供了使用这些化合物调节角鲨烯合成酶表达以及诊断和治疗与角鲨烯合成酶表达相关疾病的方法。
• BIPHENYLYLQUINUCLIDINES, USEFUL AS SQUALENE SYNTHETASE INHIBITORS
  申请人：ZENECA LIMITED

  公开号：EP0569564B1

  公开（公告）日：1997-12-29
• PROCESS FOR PRODUCING POLYDIENES
  申请人：Bridgestone Corporation

  公开号：EP2619233A1

  公开（公告）日：2013-07-31
• BULK POLYMERIZATION OF CONJUGATED DIENES USING A NICKEL-BASED CATALYST SYSTEM
  申请人：Bridgestone Corporation

  公开号：EP2658887A1

  公开（公告）日：2013-11-06
• Bulk Polymerization Of Conjugated Dienes Using A Nickel-Based Catalyst System
  申请人：McCauley Kevin M.

  公开号：US20130281642A1

  公开（公告）日：2013-10-24

  A process for preparing a polydiene, the process comprising the step of polymerizing conjugated diene monomer with a nickel-based catalyst system, where said step of polymerizing takes place within a polymerization mixture that includes less than 20% by weight of organic solvent based on the total weight of the polymerization mixture, where the temperature of the polymerization mixture is maintained below 34° C. during said step of polymerizing, and where the conversion of the conjugated diene monomer is maintained below 30%.