4-hydroxy-1-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-1,3-dihydrobenzimidazol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-hydroxy-1-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-1,3-dihydrobenzimidazol-2-one
• 英文别名: 7-hydroxy-3-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one
• 化学式: C₂₀H₂₁F₃N₄O₂
• 分子量: 406.408
• InChiKey: YLVBKSCNROEACE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  59
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• BENZIMIDAZOLONE DERIVATIVES HAVING MIXED SEROTONINE AND DOPAMINE RECEPTORS AFFINITY
  申请人：BOEHRINGER INGELHEIM ITALIA S.p.A.

  公开号：EP1218352B1

  公开（公告）日：2004-05-12
• Sexual desire enhancing medicaments comprising benzimidazolone derivatives
  申请人：Ceci Angelo

  公开号：US20070123540A1

  公开（公告）日：2007-05-31

  The invention relates to the use of benzimidazolone derivatives of formula (I) for the preparation of a medicament for the treatment of sexual desire disorders.
• Benzimidazolone Derivatives For the Treatment of Premenstrual and Other Female Sexual Disorders
  申请人：Ceci Angelo

  公开号：US20080242679A1

  公开（公告）日：2008-10-02

  The invention relates to the use of benzimidazolone derivatives of formula (I) for the preparation of a medicament for the treatment of premenstrual and other female sexual disorders.
• Benzimidazolone Derivatives for the Treatment of Urinary Incontinence
  申请人：Baiker Wolfgang

  公开号：US20090176698A1

  公开（公告）日：2009-07-09

  The invention relates to compositions comprising benzimidazolone derivatives of formula (I), optionally in form of the free base or in form of the pharmacologically acceptable acid addition salts thereof and methods of treating or preventing urinary incontinence, comprising the administration of a therapeutically effective amount of compound of formula (I), wherein R 1 , R 2 , R 3 , and R 4 denote hydrogen or hydroxy with the proviso that R 1 , R 2 , R 3 , and R 4 cannot simultaneously represent hydrogen, optionally in form of the free base or in form of the pharmacologically acceptable acid addition salts thereof.
• US6281218B1
  申请人：——

  公开号：US6281218B1

  公开（公告）日：2001-08-28